Results 41 to 50 of about 4,198,954 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Exploring the evidence base : an overview of the literature on the economic impact of knowledge transfer [PDF]

open access: yes, 2008
This paper presents a policy-focused overview of relevant extant and ongoing research relating to the economic impact of knowledge transfer from higher education institutions.
Kelly, Ursula
core  

Rethinking higher education and its relationship with social inequalities: Past knowledge, present state and future potential [PDF]

open access: yes, 2017
The purposes and impact of higher education on the economy and the broader society have been transformed through time in various ways. Higher education institutional and policy dynamics differ across time, but also between countries and political regimes
Kromydas, Theocharis
core   +2 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Education Policy and Education Opportunities

open access: yesПроблеми на постмодерността, 2012
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Svetlana Hristova
doaj  

Impact of COVID-19 on the psychological and behavioral health of college students worldwide: a knowledge mapping approach

open access: yesHumanities & Social Sciences Communications
The outbreak of COVID-19 had a significant impact on the psychological and behavioral health of college students. However, few studies have systematically explored the relationship between COVID-19 and psychological and behavioral health among college ...
Jian Li, Eryong Xue, Biyun Liu, Qing Han
doaj   +1 more source

Start Here, Or Here, No Here: Introductions to Rethinking Education Policy and Methodology in a Post-Truth Era

open access: yesEducation Policy Analysis Archives, 2018
This special issue takes up urgent questions about how we education scholars might think and do policy and methodology in what has come to be known as the post-truth era.
Jennifer R. Wolgemuth   +4 more
doaj   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock   +4 more
wiley   +1 more source

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