Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Research on the Evaluation System for Teaching Quality in Physical Education Classes at General Universities Based on Fuzzy Mathematics [PDF]
Xuejie Liu, Rongrong Wang, Huiru Song
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Bridging the Implementation Gap in AI-Powered Personalized Education: A Systematic Review of Learning Style Prediction and Recommendation Systems [PDF]
Maryam Khanian Najafabadi +4 more
openalex +1 more source
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Editorial: Gender-specific inequalities in the education system and the labor market. [PDF]
Blossfeld PN, Pratter M, Uunk W.
europepmc +1 more source
Construction and Optimization of an Intelligent Recommendation System for Ideological-Political Education in Business Administration Courses: Integrating K-Means Clustering and NLP Analysis [PDF]
Ling Lu, Jiang Yong Lu, Li Wang
openalex +1 more source
Examining the impact of audience response systems on student performance in anatomy education: a randomised controlled trial [PDF]
Stuart J Fergusson +7 more
openalex +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source

