ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Questionnaire survey on the satisfaction of SimEx dental education system. [PDF]
J Dent Sci, 2023 Hong G +8 more
europepmc +1 more source
The Reform and Coping Strategies of Education Management System in the Era of Artificial Intelligence [PDF]
Xia Di
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Development of secondary education in Bessarabia in 1833-1871
Tyragetia, 2014 In this article we will analyze the development of the secondary education system in Bessarabia since 1833, when the first secular secondary public school was opened, until 1871, when the Russian Empire carried out a series of reforms, which affected the
Tatiana Chicaroş
doaj
Retracted: Emotional Intervention and Education System Construction for Rural Children Based on Semantic Analysis. [PDF]
Occup Ther Int, 2023 International OT.
europepmc +1 more source
Education system, labour market and education system graduates employment in Romania [PDF]
, 2012 The objective of our paper is to highlight and analyse certain aspects related to the education system, labour market and education system graduates employment in Romania. It starts by pointing out the importance of education and some of the transformations the Romanian education system has undertaken after 1989 and during the process of passage to the
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
An exploration of instructional design for graduate education system in biomedical science: a mixedmethod design. [PDF]
BMC Med EducKim M, Lim C.
europepmc +1 more source
Value of the stroke 1-2-0 prehospital stroke education system: the experience of a general practitioner team. [PDF]
BMC Neurol, 2023 Liu Y +6 more
europepmc +1 more source