Results 61 to 70 of about 1,330,224 (318)

TechMIS Special Report (September 2003) [PDF]

open access: yes, 2003
A special alert analyzing how to provide for supplemental education services directly or through a high-performing ...
Education Turnkey Systems
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

TechMIS Funding Alert (February 10, 2009) [PDF]

open access: yes, 2009
A funding alert on the economic stimulus package from the Senate regarding education funding.
Education Turnkey Systems
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

TechMIS Newsletter (February 2001) [PDF]

open access: yes, 2000
The February 2001 newsletter included a memorandum to subscribers from Charles Blaschke, a special report on President Bush s proposed education policies, and state profile ...
Education Turnkey Systems
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

TechMIS Sequestration Update (July 24, 2012) [PDF]

open access: yes, 2012
An update on the potential sequestration and its impact on the education spending with an introductory memorandum from Charles Blaschke, Blair Curry, and Suzanne ...
Education Turnkey Systems
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

TechMIS Special Report (December 12, 2006) [PDF]

open access: yes, 2006
A Special Report with introductory memorandum from Charles Blaschke on a report from USED recommending that districts identified for improvement be allowed to provide supplemental education services (SES)
Education Turnkey Systems
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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