Results 41 to 50 of about 1,330,224 (318)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
TechMIS Special Report (May 13, 2009) [PDF]
, 2009 A special report analyzing the proposed FY 2010 education budget with introductory memorandum from Charles Blaschke and Blair ...
Education Turnkey Systems
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
TechMIS Funding Alert (February 12, 2009) [PDF]
, 2009 A memorandum from Charles Blaschke updating subscribers on the status of the education funding stimulus ...
Education Turnkey Systems
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
TechMIS Memorandum (February 2003) [PDF]
, 2003 A memorandum from Charles Blaschke summarizing the FY 2003 Omnibus Appropriation Bill and its impact on education ...
Education Turnkey Systems
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
TechMIS Funding Alert (February 17, 2009) [PDF]
, 2009 A funding alert updating the report from February 12, 2009 regarding the economic stimulus package for ...
Education Turnkey Systems
core
Effect of yogic education system and modern education system on memory
International Journal of Yoga, 2009 Memory is more associated with the temporal cortex than other cortical areas. The two main components of memory are spatial and verbal which relate to right and left hemispheres of the brain, respectively. Many investigations have shown the beneficial effects of yoga on memory and temporal functions of the brain.
Rangan R, Nagendra H, Bhat G
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source