Results 41 to 50 of about 1,071,732 (269)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

An exploratory analysis of divergent patterns in reading progression during a tablet-based literacy program

open access: yesFrontiers in Education, 2023
We conducted exploratory research on divergent patterns in reading progression among early grade learners in a low-resourced community to identify key determinants of high versus low reading progress. The sample comprised 30 learners who were purposively
Sarah Bardack   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The Use of Metaverse in the Health-care System: A Scoping Review Article

open access: yesHail Journal of Health Sciences
The metaverse functions as a spatial computing platform that integrates both the physical and virtual realms, enabling individuals to engage with holographic elements within an environment facilitated by advanced technologies such as augmented reality ...
Rafiuddin Mohammed, Ahmed Albarrak
doaj   +1 more source

Defining and modeling of students’ professional thinking development dependence on their training process organization

open access: yesCTE Workshop Proceedings, 2019
The professional thinking issues are analyzed in the research. The authors pointed that the technical thought concepts, images and practical actions are in a complex and dynamic interaction with each other.
Andrey I. Kupin   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The Technology Imperative in Education [PDF]

open access: yes, 2001
The technological imperative can be an insidious master. It can become the central goal of our endeavors rather than just one way through which goals can be reached. This misdirection can have very real and lasting consequences. For this reason, the basis for action in terms of information systems development and implementation must be kept visible to ...
William T. Bonner, Abhijit Gopal
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy