Results 81 to 90 of about 627,737 (260)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Shuttered Public Schools: The Struggle to Bring Old Buildings New Life [PDF]
, 2013 Large-scale public school closures have become a fact of life in many American cities, and that trend is not likely to stop now. This report looks at what happens to the buildings themselves, studying the experiences of Philadelphia and 11 other cities ...
Emily Dowdall, Susan Warner
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Sustainability in Education Buildings
International Online Journal of Educational Sciences, 2016 Article History: Received 09.09.2015 Received in revised form 15.01.2016 Accepted 25.03.2016 Available online 15.07.2016 Increasing of the world population and unlimited human needs lead to rapid depletion of limited natural resources. Sustainable design approach is determined as a solution to environmental problems which are triggered by this ...
KOCABAŞ, İbrahim, Bademcioğlu, Mehtap
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Urban ScienceNowadays, reducing energy consumption and obtaining thermal comfort are significant for making educational buildings more climate resilient, more sustainable, and more comfortable.
Cihan Turhan +4 more
doaj +1 more source
Closing Public Schools in Philadelphia: Lessons From Six Urban Districts [PDF]
, 2011 Examines cost savings, impact on student performance, and political fallout from large-scale school closings in six cities. Outlines lessons such as the need to convince the community early of necessary closings and establish clear, quantifiable ...
core
Set Free the Artistic Energy of Lodz! The Evolution of the Urban Forms Foundation [PDF]
, 2016 The text discusses the complex characteristics of the activities of the Urban Forms Foundation, its goals, methods and areas of activity as well as recent ...
Mróz, Jowita
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The Influence of Church Architecture on Urbanism in Cities [PDF]
, 2015 Since the beginnings of urban development, church buildings have been integral parts of cities, integral parts of Central European urban societies. For most of the time the Church fulfilled not only its pastoral function, but also played an important ...
Veselý, Josef
core +1 more source