Results 61 to 70 of about 347,417 (324)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Application of Data Mining Techniques in Determining the Accuracy of the Models Predicting the Student Academic failure

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2020
Introduction: Student academic failure is one of the shortcomings of higher education system. A system with the ability to predict and prevent the academic failure can play a decisive role in enhancing the quality of education.
Azadeh Fadavi, Keyvan Salehi, Ebrahim Khodaie, Ali Moghadamzadeh, Mohammad Javadipour   +4 more
doaj  

Situating multimodal learning analytics [PDF]

, 2016
The digital age has introduced a host of new challenges and opportunities for the learning sciences community. These challenges and opportunities are particularly abundant in multimodal learning analytics (MMLA), a research methodology that aims to ...
Abrahamson, D, Blikstein, P, Grover, S, Schneider, B, Tissenbaum, M, Worsley, M   +5 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Educational Data Mining untuk Meningkatkan Pendukung Keputusan dalam Sistem Informasi Sekolah [PDF]

, 2015
Educational Data Mining adalah disiplin yang muncul berkaitan dengan pengembangan metode untuk mendapatkan informasi unik dari dataset yang berasal dari pendidikan.
Hidayat, M. M. (M)
core   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Integration of Data Mining Clustering Approach in the Personalized E-Learning System

IEEE Access, 2018
Educational data-mining is an evolving discipline that focuses on the improvement of self-learning and adaptive methods. It is used for finding hidden patterns or intrinsic structures of educational data. In the arena of education, the heterogeneous data
Samina Kausar, Xu Huahu, Iftikhar Hussain, Zhu Wenhao, Misha Zahid   +4 more
doaj   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Methods of teaching educational data mining for pedagogical students

Открытое образование (Москва), 2019
The aim of the article is to discuss and argue teaching educational data mining for pedagogical stu-dents and to describe the methodical system of educational data mining teaching for students with a middle level of mathematical and IT disciplines, that ...
E. A. Terbusheva
doaj   +1 more source

Coupling analysis in educational data [PDF]

, 2015
University of Technology Sydney. Faculty of Engineering and Information Technology.Educational data analysis refers to techniques, tools, and research designed to automatically extract meaning from large repositories of data generated by or related to ...
Li, Mu
core