Results 61 to 70 of about 1,338,488 (289)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

All Talk and No Action? Racial Differences in College Behaviors and Attendance [PDF]

open access: yes, 2018
According to the influential “oppositional culture” account, we should expect black students as a group to be less likely to engage in school than their white counterparts because they are more likely to believe and act in opposition to academics.
Blake, Mary Kate
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Does Ethnicity Moderate the Longitudinal Change in Adolescent Educational Expectations for University Study between ages 14-16? Understanding Differences among White, Indian, Pakistani, Bangladeshi and Black Caribbean Pupils in England [PDF]

open access: yesAthens Journal of Education, 2015
Previous research has established that adolescent educational expectations for university study differ widely across UK ethnic minorities. This quantitative study explores change in expectations over time and across UK ethnic groups in a psychometric ...
Michael Tzanakis
doaj   +1 more source

Unmet goals of tracking: within-track heterogeneity of students' expectations for [PDF]

open access: yes, 2015
Educational systems are often characterized by some form(s) of ability grouping, like tracking. Although substantial variation in the implementation of these practices exists, it is always the aim to improve teaching efficiency by creating homogeneous ...
Demanet, Jannick   +2 more
core   +1 more source

Interdistrict Choice and Teacher Beliefs: Implications for Educational Expectations, Equity, and Policymaking [PDF]

open access: yes, 2020
Interdistrict choice, which allows families to choose between schools outside of their districts of residence, is currently serving more students than any other choice program in the United States.
Ambroso, Eric P   +2 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

School Influences on Parents’ Educational Expectations [PDF]

open access: yes, 2012
This study seeks to determine the social origins of parents\u27 educational expectations for their children and explore how the effects of sociodemographic background characteristics differ across schools. Using data from the Early Childhood Longitudinal
Lawrence, Elizabeth M.
core   +2 more sources

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