Results 71 to 80 of about 4,485,853 (255)
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017 Background. Left-sided portal hypertension (LSPH) is a rare cause of bleeding. Aim. To analyse the outcomes of roentgen-endovascular embolization of the splenic artery (RESA) in recurrent bleeding from fundal gastric varices (FGV) secondary to LSPH ...
Mahiliavets E. V. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ISOLATED HYDROPERICARDIUM – THE IMPLICATION OF LATE DIAGNOSIS OF PRIMARY HYPOTHYROIDISM
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017 Background. In therapeutic practice the diagnostics of hypothyroidism can be difficult due to its non-specific nature and symptoms diversity. Goal.
Snitko V. N. +3 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2014 Strategies designed to increase the participation of youth from traditionally underrepresented backgrounds in higher education in Australia have had little impact.
Holmes, Kathryn (R18458) +6 more
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018 The article presents a case of diagnosis and treatment of Wolff-Parkinson-White syndrome combined with early ventricular repolarization syndrome in a 19-year-old patient.
Shpak N. V. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source