Results 81 to 90 of about 1,575,689 (300)

Methodology and technology assessment of educational institution [PDF]

, 2012
У посібнику викладено наукові засади і практичні рекомендації з організації і проведення моніторингу якості освіти, оцінювання діяльності загальноосвітніх навчальних закладів. Для керівників навчальних закладів, управлінців, педагогічних працівників.The
Булах, І.Є., Лукіна, Т.О., Ляшенко, О.І., Мруга, М.Р.   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ACUTE FLEGMONOUS DIVERTICULITIS OF JEJUNUM AS A CAUSE OF DIFFUSE PURULENT PERITONITIS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
Background. Diverticulum of the small intestine is a pathological saccate protrusion, which communicates directly through the opening with the cavity of the organ.
Dziashuk A. N., Tsylindz I. Т., Avdeeva Е. Y.   +2 more
doaj   +1 more source

Management education environment higher education institution: the essence of the concept [PDF]

, 2014
У статті на основі аналізу наукових підходів до тлумачення сутності понять «управління», «освітнє середо-зище вищого навчального закладу» та з урахуванням особливостей цих феноменів сформульовано зміст поняття «управління освітнім середовищем вищого ...
Братко, Марія Василівна
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

EXPERIMENTAL MORPHOLOGICAL ASSESSMENT OF TOXIC LIVER DAMAGE IN ADMINISTRATION OF IMMUNODEPRESSANT MICOPHENOLATE MOFETYL

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017
Background. Drugs that have an immunosuppressive effect possess a wide spectrum of hepatotoxic effects. Aim of the study. To study the effect of the drug mycophenolate mofetyl (MMF) on the structure of liver tissue in rats. Material and methods.
Kurbat M. N., Kravchuk R. I., Astrowskaja A. B.   +2 more
doaj   +1 more source

Модели эффективного аутсорсинга для реализации в образовательном учреждении [PDF]

, 2014
The article considers the task of choosing a model of effective outsourcing educational institution, application outsourcing model on the basis of of the educational ...
Азизянц, В. Д., Картуков, К. С., Лызин, И.   +2 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017
Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value ...
Doroshenko Ye. M., Snezhitsky V. A., Lelevich V. V.   +2 more
doaj   +1 more source