Results 41 to 50 of about 458,823 (302)
Cyclicity of motivation as a factor in control staff in innovative organizations
Вестник Северо-Кавказского федерального университета, 2022 The article is devoted to questions of recurrence of motivation in human resource management of the innovative organizations and to theoretical researches of the nature of its phenomenon and studying for improvement of techniques of stimulation and ...
I. V. Mandritsa, T. A. Doroshewskya
doaj
Preparation and Statistical Modeling of Solid Lipid Nanoparticles of Dimethyl Fumarate for Better Management of Multiple Sclerosis [PDF]
Advanced Pharmaceutical Bulletin, 2018 Purpose: The objective of this study was to synthesize and statistically optimize dimethyl fumarate (DMF) loaded solid lipid nanoparticles (SLNs) for better management of multiple sclerosis (MS).
Smriti Ojha, Babita Kumar
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Design, synthesis and anticancer activity of naphthoquinone derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Basis on molecular docking and pharmacophore analysis of naphthoquinone moiety, a total of 23 compounds were designed and synthesised. With the help of reverse targets searching, anti-cancer activity was preliminarily evaluated, most of them are ...
Xiao-bao Shen +5 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Tadris: Jurnal Keguruan dan Ilmu Tarbiyah, 2021 Land as school infrastructure is often neglected in the certification process. This research emphasized that school land certification is essential and whether it automatically includes authority over everything on it, what land rights can be given to ...
Zefrizal Nurdin
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Educational Opportunities and the Role of Institutions [PDF]
Educational opportunities determine the intergenerational mobility of human capital and are affected by institutional features of schooling systems. The aim of this paper is twofold.
Ammermüller, Andreas
core +2 more sources
Scientific ReportsUncertainty principle establishes a remarkable lower bound to predict the measured outcome of two non-commuting observables. In this paper, based on the quantum renormalization-group method, we study the relation between quantum-memory-assisted entropic ...
Cheng-Cheng Liu +6 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source