Results 121 to 130 of about 3,845,941 (373)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Correction: Demobilizing knowledge in American schools: censoring critical perspectives

open access: yesHumanities & Social Sciences Communications, 2023
Dustin Hornbeck, Joel R. Malin
doaj   +1 more source

ACHIEVING GENDER EQUALITY AND WOMEN LEADERSHIP IN A SELECTED STATE UNIVERSITY IN ZIMBABWE: A FEMINIST CAPABILITIES APPROACH

open access: yesAfrican And Global Issues Quarterly
Despite international efforts towards gender equality, universities in developing countries including Zimbabwe continue to grapple with underrepresentation of women in leadership positions.
Annah Moyo, Wonder Muchabaiwa
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Distributed Leadership:Still in the gift of the headteacher [PDF]

open access: yes, 2013
Contemporary efforts to reconceptualise the teaching profession in Scotland as seen with the Donaldson (2011) "Review of Teacher Education," the McCormac (2011) "Review of Teacher Employment" and the GTCS (2012) "Review of Professional Standards" are ...
Torrance, Deirdre
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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