Results 81 to 90 of about 1,310,505 (277)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Cultivating Contextual Attributes in the Integration of Latin@ Educational Leadership [PDF]

, 2018
Although the Latino population is growing rapidly in the United States, there is a disproportionate paucity of literature on the perspectives and challenges of Latino/a educational leaders.
Castillo, Yuleinys A, Maniss, Suzanne
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Portrait methodology and educational leadership : putting the person first [PDF]

, 2009
This article describes a variant on a methodological approach which provides ways of developing educational leaders' understandings of themselves and their situation through the production of individually written 'portraits' which focus upon the ...
Bottery, Michael, Ngai, Siu Keung George, Wong, Ping Man, Wright, Nigel   +3 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Revisiting management of high school teachers during Covid-19: Implication for leadership contingency

International Journal of Educational Management and Development Studies
The period of Covid-19 outbreak led to the interruption of normal school functionality due to unprecedented turmoil in the management of high school subject teachers worldwide.
Simanga Phillip Lukhele, LDM Lebeloane
doaj   +1 more source

Leadership as an Act of Love: Leading in Dangerous Times

Frontiers in Education, 2019
This essay is an invitation to engage in a heart-whole thought experiment around the possibilities and potential of framing leadership as an act of love.
Mónica C. Byrne-Jiménez, Irene H. Yoon
doaj   +1 more source

Educational Leadership for Results or for Learning? Contrasting Directions in Times of Transition [PDF]

Educational leadership, like educational systems and schooling, is steered by the national political, professional and social contexts in which it occurs.
David Oldroyd
core  

Evidencing the development of distributed leadership capacity in the quality management of online learning environments (OLEs) in Australian higher education [PDF]

, 2011
The poster will present findings from the first year of a two-year nationally funded Australian Learning and Teaching Council (ALTC) project, Building distributed leadership in designing and implementing a quality management framework for Online Learning
Gosper, Maree, Hicks, Margaret, Hollenbeck, Robert, Holt, Dale, Louka, Amgad, Munro, Judy, Palmer, Stuart, Quealy, James, Sankey, Michael, Solomonides, Ian   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source