Results 51 to 60 of about 380,132 (314)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Audiovisual media in the universities of Russia: typology and analysis of the content

RUDN Journal of Studies in Literature and Journalism, 2022
The authors give the typology of the audiovisual media in the universities of Russia. Also, the very process of producing is analyzed. The special educational and cognitive process of media producing are considered as elements of information, internal ...
Svetlana L. Urazova, Ekaterina B. Gromova, Ksenia E. Kuzmenkova, Yulia P. Mitkovskaya   +3 more
doaj   +1 more source

Newsletter of Commonwealth Educational Media Centre for Asia (vol 6, no 2 & 3)

, 2020
CEMCA newsletter published April & July ...

core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Malleability of Higher Education Study Environment Factors and Their Influence on Humanities Student Dropout—Validating an Instrument

Education Sciences
In this article, we investigate how tertiary humanities students’ perceptions of the study environment, dropout considerations, and background variables, respectively, explain variations in dropout.
Ane Qvortrup, Eva Lykkegaard
doaj   +1 more source

Phenomenological Study of the Parents’ Religious Teachings to Preschool Students [PDF]

علوم تربیتی از دیدگاه اسلام, 2018
The purpose of the study is the phenomenological study of the parents’ religious teachings to preschool students in Urmia in the academic year of 1397-96.
Javad Keyhan, samira zeynalpour
doaj   +1 more source

Parents’ Media Education as a Component of Media Education Space

Naukovì pracì Nacìonalʹnoï bìblìoteki Ukraïni ìmenì V Ì Vernadsʹkogo, 2020
The article presents the study of the problem of parents’ media education as an important component in creating a coherent media education system in Ukraine. Formation of parents’ media literacy and media culture is considered as an important factor in the early socialization of the child, his/her protection against negative information influences and ...
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source