Results 71 to 80 of about 12,528,727 (304)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Educational Needs Assessment of Diabetic Pregnant Mothers in Meshgin Health Centers in 2018

open access: yesJournal of Ardabil University of Medical Sciences, 2019
Background & objectives: Gestational diabetes is one of the most common medical problems during pregnancy, which has many negative consequences for mother and fetus.
Marziyeh Avazeh   +4 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Educational assesment in training of competent doctors in ukraine: problems and their decision

open access: yesОсвітологія, 2016
In article deals with the problem of the use of educational assessment in the training of future doctors in Ukraine. The key role of educational assessment in the improvement of the quality of higher medical education was defined.
Kulbashna Yaroslava, Astapenko Olena
doaj   +1 more source

Exploring the process of educational change in English medium senior secondary school Assessment in Vanuatu [PDF]

open access: yes, 2013
Educational change is ongoing. It is generally aimed at improving teaching and learning, but usually comes with challenges. Scholars have devoted a great deal of research to minimise the challenges faced by implementers of change, but there is no one ...
Tarosa, Gayleen Harrison
core  

Method Effects and the Need for Cognition Scale [PDF]

open access: yes, 2012
Individual differences in the need for cognition are typically assessed using the 18-item Need for cognition scale (NCS) developed by Cacioppo and Petty (1982).
Ni Chuinneagain, S   +5 more
core   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Need Assessment For Sex Educational Amongst The School Children

open access: yesIndian Journal of Community Medicine, 1998
Research question: Will the sex education given to the students help in STD prevention, population control and in their future sex life. Hypothesis : In order to have a successful school based sex education programme, it is necessary to involve the ...
Thakor H.G, Kumar P
doaj  

Promoting emotional, social and civic competencies: Educational policies in Spain [PDF]

open access: yes, 2013
This article analyzes Spain’s educational policies in terms of emotional, social, and civic competencies. The need to teach these competencies at school is justified socially and pedagogically, and the way in which these competencies are implemented in
Romero Pérez, Clara   +1 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

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