Results 91 to 100 of about 8,110,481 (306)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Encontros e desencontros de crianças e adultos na Educação Infantil: uma análise a partir de Martin Buber

Pro-Posições
Resumo Este artigo apresenta pesquisa sobre práticas e interações em creches e pré-escolas, identificando convergências e divergências. O referencial teórico se baseia na filosofia do diálogo de Martin Buber, e o metodológico, na sociologia da infância ...
Sonia Kramer, Maria Fernanda Rezende Nunes, Alessandra Evelin Brandolim Pacheco, Andrea Ferreira Campos Oliveira, Aline Lopes Martins   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Lesson Enactments: Maintenance in Everyday Educational Practice. [PDF]

Postdigit Sci Educ, 2023
Mörtsell S.
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Practitioners' perspectives on spatial reasoning in educational practice from birth to 7 years. [PDF]

Br J Educ Psychol, 2023
Bates KE, Williams AY, Gilligan-Lee KA, Gripton C, Lancaster A, Williams H, Borthwick A, Gifford S, Farran EK.   +8 more
europepmc   +1 more source

Education - an Impossible Practice?

Scottish Educational Review, 2008
This article explores theoretically the argument that education is an impossible practice as it cannot mandate the future. The significance of this is that educational practice needs to be developed through the values of fallibility, conditionality and responsibility.
openaire   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Seeing through transparency in education reform: Illuminating the “local”

Education Policy Analysis Archives, 2016
Utilizing “assemblage,” a notion associated with Actor-Network Theory (ANT), we explore what discourses of transparency can, and cannot, accomplish in a network of education reform that includes schools, government agencies, and community organizations ...
Jill Koyama, Brian Kania
doaj   +1 more source

A Study on Satisfaction and Influencing Factors of Educational Practice of Preschool Education Majors in Higher Vocational Colleges. [PDF]

Front Psychol, 2022
Xiong J, Kou H, Zhang F, Kong W.
europepmc   +1 more source