Results 51 to 60 of about 540,564 (313)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
THE COMMUNITY OF PRACTICE IN THE EDUCATION
Journal of Research and Innovation for Sustainable Society, 2019 A community of practice is a group of people who share a concern, a set of problems or a passion about a common topic, a passion for a professional or personal activity. Universities may be regarded as professional communities in which joint activities are carried out, with well-defined structures.
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Des « bilingues scolaires » dans le paysage sociolinguistique breton ?
La Bretagne Linguistique, 2022 As an extension of the work carried out in the Breton field about the school bilingualism of young children, this article presents to discussion the relevance of determining and mobilizing a new notion in connection with this research object, the notion ...
Catherine Adam
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A tale of two OEPs? Looking at open educational practices from a policy viewpoint [PDF]
, 2021 This workshop will engage participants in a discussion of the apparent “understanding gap” between the two OEPs of open educational practices and open education policies, with the aim of ensuring the recognition of existing, successful open practices ...
Atenas, Javiera +2 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Educational Practices in Technical Schools in Argentina: A Case Study in Neuquen
, 2020 This work is proposed to analyze senses and possibilities of educational practices that take place in technical schools of Neuquen Province Argentina Therefore we focus in technical middle school education and training processes integrations to ...
Natalia Noemi Fernandez
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