Results 91 to 100 of about 2,609,018 (333)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

open access: yesAdvanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin   +11 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Putting it to the test [PDF]

open access: yes, 2004
THE BPS Steering Committee on Test Standards (SCTS) has already developed and introduced standards for testing in occupational settings - the Level A and Level B Certificates of Competence in Occupational Testing - to encourage responsible test use by ...
Boyle, James
core   +1 more source

Direct Growth of Transparent Boron Nitride Neutron Shielding Layer for Space Window

open access: yesAdvanced Science, EarlyView.
Direct growth of sp2‐sp3 hybridized BN (HBN) on quartz, enabled by an h‐BN buffer, produces transparent and stable films up to 80 µm thick with high transmittance and strong neutron shielding, making HBN a promising candidate for space windows in long‐term lunar missions.
Dobin Kim   +15 more
wiley   +1 more source

El programa de las asignaturas como un primer criterio para la enseñanza de la ciencia [PDF]

open access: yesCuadernos Hispanoamericanos de Psicología, 2012
In this study, the criteria used as selectors to include the different elements of a course of the curriculum of a psychologist training are analyzed.
Tiberio Pérez Manrique
doaj  

A comfirmatory factor analysis of a newly integrated multidimensional school engagement scale [PDF]

open access: yes, 2008
Inconsistencies in measures of school engagement in the literature have called for a re-conceptualization of the school engagement construct. Although many researchers view school engagement as a multifaceted construct, to our knowledge, none of the ...
Awang Hashim, Rosna, Murad Sani, Azlina
core  

Interprofessional education for first year psychology students: career plans, perceived relevance and attitudes [PDF]

open access: yes, 2014
Undergraduate psychology students have been largely excluded from interprofessional education (IPE) initiatives. In contrast to many health professions, undergraduate psychology students do not engage in work placements as part of their degree, and many ...
Barr H.   +6 more
core   +3 more sources

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

open access: yesAdvanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi   +15 more
wiley   +1 more source

Educational Psychologists Training Problems in the Field of Prevention of Suicidal Behavior of Adolescents and Youth

open access: yesПсихология и право, 2019
The article presents the results of a study of the training problems of educational psychologists aimed to prevent suicidal behavior of adolescents and youths. The data were obtained on the basis of a survey of psychologists and experts.
Vihrisuk O.V.   +2 more
doaj   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

open access: yesAdvanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou   +12 more
wiley   +1 more source

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