Results 61 to 70 of about 421,249 (310)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Train to include – the promotion of inclusive practice through training in context. [PDF]

, 2015
The project "Training to Include" was aimed at promoting inclusive practices through training in context of professionals from various educational levels.
Luís, Helena, Papamikail, Lia, Piscalho, Isabel   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Public Discussions on the Reform of the City Electoral System of the Russian Empire at the Turn of the 20th Century

Historia provinciae: журнал региональной истории
The article is devoted to the problem of reforming city elecgtroral system, which was raised in the works of political writers, economists, jurists, and local government officials of the Russian Empire at the turn of the 20th century.
Sorokin Aleksandr A.
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Employment and Productivity: Disentangling Employment Structure and Qualification Effects [PDF]

International Productivity Monitor, 2012
Based on a disaggregation of the workforce into three qualification or educational attainment categories, the article estimates the effects on hourly productivity from changes in the employment rate structure and from changes in the qualification ...
Renaud Bourlès1, Gilbert Cette, Anastasia Cozarenco   +2 more
doaj  

Riding the Waves of Reforms in Corporate Law, an Overview of Recent Improvements in Italian Corporate Codes of Conduct [PDF]

This paper provides an exploratory analysis on the relationship between educational qualification and work status in Italy, with a particular focus on entrepreneurs and self-employed workers.
Fabio Sabatini
core  

Collection of educational resources for health professionals qualification [PDF]

, 2016
Apresenta as evoluções e decisões tomadas no processo de design e desenvolvimento do ARES, por meio de uma linha do tempo que expõe as principais novidades e funcionalidades da versão atual do ...
Jacob, Aline Santos, Lacerda, Soraya Alves, Monteiro, Fernanda de Souza, Oliveira, Vinicius de Araújo   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Human Resources Potential of Ukrainian Industry: Challenges and Directions for Strengthening the Resilience [PDF]

Problemi Ekonomiki
Post-war reconstruction of industry in Ukraine is impossible without the creation of appropriate conditions for the restoration of human resources potential, as well as ensuring its development and effective use.
Azmuk Nadiya A.
doaj   +1 more source