Results 61 to 70 of about 424,348 (309)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Qualifications in clinical education for psychiatrists [PDF]

Psychiatric Bulletin, 2007
We were interested to read the article by Dinniss et al (Psychiatric Bulletin, March 2007, 31 , 107–109) on qualifications in clinical education for psychiatrists. We wish to draw attention to postgraduate programmes in medical education (including MSc, PGDip and PGCert) run by Durham University,
John McLachlan, Sharyn Maxwell
openaire   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Inclusion or diversion in higher education in the Republic of Ireland? [PDF]

, 2009
In this paper I investigate the extent to which the Irish higher education system promotes inclusion or diversion in relation to social selectivity. In doing so, stratification processes are examined for two educational outcomes: inequality in the type ...
Byrne, Delma
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Collection of educational resources for health professionals qualification [PDF]

, 2016
Apresenta as evoluções e decisões tomadas no processo de design e desenvolvimento do ARES, por meio de uma linha do tempo que expõe as principais novidades e funcionalidades da versão atual do ...
Jacob, Aline Santos, Lacerda, Soraya Alves, Monteiro, Fernanda de Souza, Oliveira, Vinicius de Araújo   +3 more
core  

What a difference a term makes:the effect of educational attainment on marital outcomes in the UK [PDF]

, 2013
In the past, students in England and Wales born within the first 5 monthsof the academic year could leave school one term earlier than those born later inthe year.
D Lee, Dan Anderberg, E Beaujouan, E Duflo, EW Burgess, G Imbens, GS Becker, GS Becker, GW Imbens, J Angrist, J Hahn, J McCrary, JD Angrist, JR Behrman, K Konrad, L Lefgren, M Dickson, M Fort, M Peters, PA Chiappori, R Fernandez, R Fernandez, R Rockwell, TC Hunt, Yu Zhu   +24 more
core   +4 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source