Results 71 to 80 of about 671,591 (263)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
A new method for measuring the effectiveness of teacher evaluation instruments in improving pedagogical performance in higher education based on the neutrosophic 2-tuple linguistic model and offset logic, Neutrosophic Sets and Systems [PDF]
Neutrosophic Sets and SystemsAssessment in a teaching-learning process allows teachers to determine to what degree students are assimilating the content and are meeting the objectives of the study program.
Judith Ernestina Vera-León +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
SURVIVAL AND DEVELOPMENT: RESEARCH ON CHINESE HIGHER EDUCATION DURING THE WAR OF RESISTANCE AGAINST JAPANESE AGGRESSION (1931-1945) [PDF]
Geo Journal of Tourism and GeositesChina’s higher education system demonstrated remarkable resilience during the War of Resistance Against Japanese Aggression (1931–1945), a period marked by national crisis, instability, and widespread destruction.
Yanjun HUANG*
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Ra XimhaiThe ISO 21001:2018 norm is for the management systems of educational organizations, which has gained importance in the field of higher education. In addition, terminal efficiency is a crucial indicator of educational quality, therefore their relationship
Celia Yudith Bea Berrelleza +1 more
doaj +1 more source
Structural equilibrium in universities: quality, finance and sustainability from an empirical perspective: An integrative analysis with neutrosophic cognitive maps [PDF]
Neutrosophic Sets and SystemsThis study explores the structural relationships between institutional financial health and academic quality in Chilean higher education institutions (HEIs) by applying multivariate tools such as the dynamic HJBiplot and fixed-effects regression models ...
Claudio Ruff +3 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source