Results 61 to 70 of about 5,216,642 (307)
Educational Alternatives for Vulnerable Youth: Student Needs, Program Types, and Research Directions [PDF]
, 2003 Chapter 1 of this document examines the need for alternative education among vulnerable youth by reviewing the numbers and characteristics of youth who disconnect from mainstream developmental pathways in various ways.
Janine M. Zweig, Laudan Y. Aron
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Health and physical education 2013 [PDF]
In 2013 the National Monitoring Study of Student Achievement assessed student achievement in two learning areas of the New Zealand Curriculum–health and physical education, and mathematics and statistics.
Educational Assessment Research Unit (Otago) +1 more
core
Children at risk of poor educational outcomes. How educational research can support early identification and improve prevention. Special issue editorial [PDF]
, 2016 The editorial presents the papers of this special issue regarding children at risk of poor educational outcomes. The articles “provide a cross-section of the multifaceted research carried out within this framework.
Hasselhorn, Marcus, Kunter, Mareike
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2023 Unless you have specific training in social science – and specifically educational – research, the thought of doing this type of study can be a little daunting. However, with some guidance and a willingness to learn, educational research can be exciting and rewarding, particularly given the vast amounts of data generated on a regular basis within such ...
MacKay, Jill R D, Wu, Shelly
openaire
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source