Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Educational research : what strategies for development in the European Research Area? [PDF]
This is a report of the European Educational Research Journal Roundtable that sought to describe what national educational research programmes are doing, how they are working together, and how they might contribute to the developing European Educational ...
Brown, Alan
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
L’approche phénoménologique en sciences de l’éducation : quels apports méthodologiques ?
This article presents an analysis of some of the empirical data from two studies of teaching-learning situations in elementary schools. Educational situations are complex and need to be explored using a variety of approaches if they are not to be reduced
Caroline Baugey, Marie Gabriel
doaj +1 more source
The politics of being an educational researcher: minimising the harm done by research. [PDF]
Researchers have an obligation to reflect on the politics of their research and of whose interests it serves in order to take steps to minimise it being used in damaging ways. This article uses the problem of the "politics of blame"-- the way governments
Thrupp, Martin
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Design of a website for high school: exploratory-sequential study
The general purpose of the study was to develop a website to improve the teaching-learning experience of high school students. A mixed methods exploratory sequential design was followed by using the Research and Development design as a basis supported ...
Kristian Armando Pineda Castillo +2 more
doaj +1 more source
Educational effectiveness and improvement in developing societies. Some experiences from the Primary Education Quality Improvement Project in Indonesia [PDF]
The improvement of education in developing societies might benefit from theory and research on educational effectiveness. ... The research evidence points at the importance of factors at the classroom level and the relatively small possibilities that the
Creemers, Bert P. M.
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
La dialéctica en las investigaciones educativas / Dialectics in education researchs
En las investigaciones educativas se refleja la dialéctica al manifestarse contradicciones en el objeto de estudio, que se presuponen y se niegan al unísono.
Emilio Alberto Ortíz Torres
doaj +1 more source

