Results 91 to 100 of about 2,551,258 (350)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Revisiting the Sports Medicine as a specialty in professional training of sports doctors [PDF]

open access: yesСаратовский научно-медицинский журнал, 2017
 This article discusses expediency of deducing sports medicine in a separate educational specialty. Also, there is a new concept of sports medicine offered.
Razinkin S.M.   +2 more
doaj  

Ontological approach to modeling innovation processes on the example of a distributed educational network of the University

open access: yesОткрытое образование (Москва), 2019
The key task of the current stage of the education system development is the task of transition to new methods of organization and support of the educational process, allowing providing high-quality training of graduates with practical knowledge and ...
D. G. Korneev   +2 more
doaj   +1 more source

Insuring Educational Risk: Opportunities versus Income [PDF]

open access: yes
We develop a model of education where individuals face educational risk. Successfully entering the skilled labor sector depends on individual effort in education and public resources, but educational risk still causes (income) inequality. We show that an
Benjamin Weigert, Dirk Schindler
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

SCIENCE EDUCATION STANDARDS [PDF]

open access: yesChemical & Engineering News Archive, 1998
Results of the Third International Mathematics & Science Study (TIMSS) reveal that U.S. high school students are still not learning critical mathematics and science content (C&EN, March 2, page 11). But for chemistry education at least, the failing marks might have a shot at upward movement with wide distribution of the American Chemical Society's new ...
openaire   +1 more source

University drop-out. The case of Italy [PDF]

open access: yes
We combine individual and aggregate-level level data on educational attainment to study the determinants of university drop-out in Italy, one of the worst performers among developed countries.
Federico Cingano, Piero Cipollone
core  

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