Results 111 to 120 of about 2,551,258 (350)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Using metadata for content indexing within an OER network [PDF]

, 2014
This paper outlines the ICT solution for a metadata portal indexing open educational resources within a network of institutions. The network is aimed at blending academic and entrepreneurial knowledge,by enabling higher education institutions to publish ...
Carlucci, Daniela, Kitanovic, Olivera, Linzalone, Roberto, Obradovic, Ivan, Schiuma, Giovanni, Stankovic, Ranka   +5 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Planning the assessment of learning outcomes in educational programs design

Высшее образование в России, 2022
The paper is focused on the upgraded technology for educational programs design considering the assessment of learning outcomes immediately after forming the initial datafor designing the program, exactly the required competences of the graduates. Within
A. I. Chuchalin, A. V. Epikhin, E. A. Muratova   +2 more
doaj  

Development of Communication Skills of Second-Graders: Features of the Implementation of the Requirements of the Federal State Educational Standard of Primary General Education

, 2023
Viktoriya V. Romanova
openalex   +2 more sources

Achieving Multidimensional Educational Goals Through Standard-Oriented Teaching. An Application to STEM Education [PDF]

, 2021
Anja Schiepe-Tiska, Anna Heinle, Paula Dümig, Frank Reinhold, Kristina Reiss   +4 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

MISADVENTURES OF ECONOMIC HISTORY IN MODERN RUSSIAN HIGHER SCHOOL: “WHO IS IN FAULT” AND “WHAT IS TO BE DONE”?

Высшее образование в России, 2022
Erstwhile the inherent subject of economists’ training program, now Economic History has in all but name disappeared from the universities’ curriculum in the view of historical redundancy.
Dmitry Y. Maidachevsky
doaj  

TEACHING PHILOSOPHY: THE PROBLEM OF COMPLIANCE OF THE SPECIFICITY OF THE EDUCATIONAL DISCIPLINE WITH THE REQUIREMENTS OF THE STATE STANDARD

, 2023
Sultanov Atabek Surenovich, Nurnazar Pirnazarov   +1 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source