Results 61 to 70 of about 2,576,100 (300)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Carnap: an Open Framework for Formal Reasoning in the Browser [PDF]
, 2018 This paper presents an overview of Carnap, a free and open framework for the development of formal reasoning applications. Carnap’s design emphasizes flexibility, extensibility, and rapid prototyping. Carnap-based applications are written in Haskell, but
Leach-Krouse, Graham
core +2 more sources
Высшее образование в России, 2016 The article discusses the changes in training programs for primary school teachers in the context of pedagogical education modernization and in accordance with the related requirements of the teacher’s professional standard.
Olga G. Smolyaninova, Vera V. Korshunova
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2015 From an educational perspective, a very important problem is that of assessment, for establishing competency and as selection criterion for different professional purposes. Among the issues to be addressed are the methods of assessment and/or the type of
Brenner, Erich +3 more
core +1 more source
The measurement of educational inequality: Achievement and opportunity [PDF]
This paper proposes two related measures of educational inequality: one for educational achievement and another for educational opportunity. The former is the simple variance (or standard deviation) of test scores.
Francisco H. G. Ferreira +1 more
core +6 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Extensión del Estándar IEEE LOM para Describir Aplicaciones Interactivas Educativas: un Enfoque sobre Accesibilidad [PDF]
, 2016 This work focuses on the use of Interactive Applications (IA) as an educational resources applied in the context of inclusive education. The Learning Object Metadata standard (LOM) is often used to facilitate the share and reuse of Learning Objects (LO).
Broisin, Julien +3 more
core +1 more source
Philosophical Competencies: What Should They Be?
Філософія освіти, 2016 The article discusses the system of general and specific competences in the educational standard of philosophy. The basic principles of developing a set of competencies. Define their relationship with the Tuning project.
Sergii Proleiev
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source