Results 91 to 100 of about 1,206,582 (283)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Solar Multi-stage Refrigeration Systems on the Basis of Absorber with the Internal Evaporative Cooling [PDF]

Problems of the Regional Energetics, 2015
In the article, the developed schematics are presented for the alternative refrigeration systems and air-conditioning systems, based on the use of absorbing cycle and solar energy for the regeneration of absorbent solution.
Doroshenko A.V., Kirillov V.H., Antonova A.R., Liudnicky K.V.   +3 more
doaj  

Evaluation of usage patterns for web-based educational systems using web mining [PDF]

, 2001
Virtual courses often separate teacher and student physically from one another, resulting in less direct feedback. The evaluation of virtual courses and other computer-supported educational systems is therefore of major importance in order to monitor ...
Donnellan, David, Pahl, Claus
core  

A Neocolonial Warp of Outmoded Hierarchies, Curricula and Disciplinary Technologies in Trinidad’s Educational System

, 2016
I re-appropriate the image of a space-time warp and its notion of disorientation to argue that colonialism created a warp in Trinidad’s educational system. Through an analysis of school violence and the wider network of structural violence in which it is
Williams, Hakim Mohandas Amani
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

New Solutions for Solar Absorption Refrigeration Systems and Air Conditioning Systems [PDF]

Problems of the Regional Energetics, 2017
The mission of the research includes the following objectives: the development of new circuit decisions for the alternate refrigerating systems based on the use of an open absorptive circuit and on the use of solar energy for absorbent solution ...
Doroshenko A.V., Antonova A.R., Liudnicky K.V., Ivanova L.V.   +3 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

HEAT EXCHANGE AND AERODYNAMICS OF THE COMBINED TUBING BUNDLES WITH CROSS INCLINED FINS [PDF]

Problems of the Regional Energetics, 2013
The paper presents results of experimental research and analyses air-side thermal performance of combined tube bundles with cross inclined fins. The empirical correlations for heat transfer and flow friction of tubes with inclined fins at different ...
Knyazyuk V. I, Lagutin A. E., , Stoyanov P. F.   +2 more
doaj  

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Kinetic Aspects of Ethylene Glycol Degradation Using UV-C Activated Hydrogen Peroxide (H₂O₂/UV-C)

Molecules
Ethylene glycol (EG) is a contaminant in the wastewater of airports because it is commonly used in aircraft deicing fluids during the cold season in northern regions. Ethylene glycol by itself has relatively low toxicity to mammals and aquatic organisms,
Timur Fazliev, Mikhail Lyulyukin, Denis Kozlov, Dmitry Selishchev   +3 more
doaj   +1 more source