Results 51 to 60 of about 5,638,928 (299)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Research on the Current Status of Inclusive Education for Children With Autism in Beijing: Perspectives From Parents of Children With Autism

International Journal of Chinese Education, 2023
To gain a comprehensive understanding of the current status of inclusive education for children with autism in Beijing from the perspectives of parents, a questionnaire-based survey was administered to 202 parents residing in Beijing, whose children have
Yingmei Mao, Qian Wang
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A seu tempo : um estudo sobre transições familiares precoces em Portugal no contexto Europeu [PDF]

Sociologia: Revista da Faculdade de Letras da Universidade do Porto, 2016
This paper critically explores the narratives associated with transitions to adulthood and focuses on the earliest occurrences of the private sphere transitions in Portugal.
Diana Carvalho
doaj   +1 more source

Recommendations for Incorporating Postsecondary and Workforce Data into Statewide Longitudinal Data Systems [PDF]

, 2010
Outlines the need for data systems to assess educational transitions, completions, and labor market outcomes of adult students and workers in postsecondary, adult education, and skill development programs in order to strengthen policies and ...
Andrew Reamer, Brandon Roberts, Evelyn Ganzglass, Rachel Unruh, Whitney Smith   +4 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Quality Counts 2009 [PDF]

, 2009
In an attempt to gauge the educational progress of the nation and each state, Education Week has published state report cards since 1997 in its annual Quality Counts series. The 13th annual report — Quality Counts 2009 — was released in early 2009.
McKenzie, Sarah C., Ritter, Gary W.
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Qualitative Work and the Testing and Development of Theory: Lessons from a Study Combining Cross-Case and Within-Case Analysis via Ragin's QCA

Forum: Qualitative Social Research, 2012
Charles RAGIN's work, especially his development of Qualitative Comparative Analysis (QCA), offers social scientists a way of bringing together the strengths of the qualitative and quantitative traditions.
Barry Cooper, Judith Glaesser
doaj