Results 51 to 60 of about 151,290 (231)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Between the University and the Monastery: The Ethiopian Church and the Transformation of Knowledge
Kulturní StudiaThis article examines the transformations of the Ethiopian Orthodox educational system ʾAbənnat Təmhərt in the context of modernity and digital culture. It argues that the Ethiopian Orthodox Church constitutes a unique case in which education, faith, and
Asrat Tsegaw, Tilahun Tsegaye
doaj +1 more source
RECEPTIVE STRATEGIES OF Y. KLAVDIEV'S PLAY "THE YAKUZA DOGS"
Вестник Кемеровского государственного университета, 2017 The article discusses the play by contemporary playwright Yuri Klavdiev "TheYakuza Dogs." Here is a detailed (but not exhaustive) analysis of the cultural codes.
T. N. Volkova
doaj +1 more source
The college students’ perspective on what makes an educator well-qualified [PDF]
Journal of Pedagogical Research, 2019 The educators of the 21st century have a great task ahead. In today’s world, the educators are expected to have a great deal of professional and personal qualities, and extraordinary skills.
John Mark R. Asio, Erin E. Riego de Dios
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversitas JournalWe are pleased to introduce the Special Issue on Sustainability in Asia-Pacific: Multidisciplinary Insights and Innovations, a collaboration between Diversitas Journal, the Asia-Pacific Consortium of Research and Educators, Inc.
Racidon Bernarte
doaj +1 more source
Открытое образование (Москва), 2018 The purpose of the study. The purpose of the study is the development and experimental approbation of the complex of organizational and pedagogical conditions for the development of the teacher’s ICT competence in the system of professional development ...
Olga A. Fadeeva
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source