EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains [PDF]
FEBS Open Bio, 2014 Diacylglycerol kinase (DGK) α, which is activated by Ca2+, contains a recoverin homology (RVH) domain, tandem repeats of two Ca2+-binding EF-hand motifs, two cysteine-rich C1 domains and the catalytic domain.
Tatsuya Yamamoto +2 more
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Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function. [PDF]
Biophys J, 2016 Cardiac gene delivery of parvalbumin (Parv), an EF-hand Ca(2+) buffer, has been studied as a therapeutic strategy for diastolic heart failure, in which slow Ca(2+) reuptake is an important contributor. A limitation of wild-type (WT) Parv is the significant trade-off between faster relaxation and blunted contraction amplitude, occurring because WT-Parv ...
Asp ML +4 more
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Two structural motifs within canonical EF-hand calcium-binding domains identify five different classes of calcium buffers and sensors. [PDF]
PLoS ONE, 2014 Proteins with EF-hand calcium-binding motifs are essential for many cellular processes, but are also associated with cancer, autism, cardiac arrhythmias, and Alzheimer's, skeletal muscle and neuronal diseases.
Konstantin Denessiouk +4 more
doaj +5 more sources
Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin. [PDF]
Cell Calcium, 2017 The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by CaM.
Xu L +4 more
europepmc +5 more sources
Experimental Insight into the Structural and Functional Roles of the ‘Black’ and ‘Gray’ Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs [PDF]
Molecules, 2019 Recently, we have found that calcium binding proteins of the EF-hand superfamily (i.e., a large family of proteins containing helix-loop-helix calcium binding motif or EF-hand) contain two types of conserved clusters called cluster I (‘black’
Sergey E. Permyakov +10 more
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Scientific Reports, 2022 Calcium (Ca2+) is well known as a second messenger in eukaryotes, where Ca2+ signaling controls life-sustaining cellular processes. Although bacteria produce the components required for Ca2+ signaling, little is known about the mechanisms of bacterial ...
Biraj B. Kayastha +16 more
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Flexibility of EF-hand motifs: structural and thermodynamic studies of Calcium Binding Protein-1 from Entamoeba histolytica with Pb2+, Ba2+, and Sr2+. [PDF]
BMC Biophys, 2012 BackgroundEF-hand proteins can be activated by the binding of various heavy metals other than calcium, and such complexes can disturb the calcium-signaling pathway and cause toxicity and disease causing state. So far, no comprehensive study has been done
Kumar S +4 more
europepmc +2 more sources
Frontiers in Plant Science, 2015 Calcium ions are considered ubiquitous second messengers in eukaryotic signal transduction pathways. Intracellular Ca2+ concentration are modulated by various signals such as hormones and biotic and abiotic stresses.
Tapan Kumar Mohanta +3 more
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Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics [PDF]
Communications BiologyIn most eukaryotes, the mitochondrial calcium uniporter (MCU) mediates Ca2+ influx into the mitochondrial matrix through a process regulated by MICUs and the EMRE.
Minwoo Jin +4 more
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Frontiers in Plant Science, 2017 Calcium ion (Ca2+) is a universal second messenger that plays a critical role in plant responses to diverse physiological and environmental stimuli. The stimulus-specific signals are perceived and decoded by a series of Ca2+ binding proteins serving as ...
Houqing Zeng +4 more
doaj +2 more sources