Results 91 to 100 of about 28,276 (232)

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy

Disease Models & Mechanisms, 2019
STIM and ORAI proteins play a fundamental role in calcium signaling, allowing for calcium influx through the plasma membrane upon depletion of intracellular stores, in a process known as store-operated Ca2+ entry.
Celia Cordero-Sánchez, B. Riva, S. Reano, N. Clemente, Ivan Zaggia, F. Ruffinatti, A. Potenzieri, T. Pirali, S. Raffa, S. Sangaletti, M. Colombo, A. Bertoni, M. Garibaldi, N. Filigheddu, A. Genazzani   +14 more
semanticscholar   +1 more source

Development of a Fiber Bundle Cell Framework for Rapid, Reliability‐Based Analysis and Design of Pseudo‐Ductile Thin‐Ply Hybrid Composites

Polymer Composites, EarlyView.
Application of the fiber bundle cell model for design or prediction of pseudo‐ductility. ABSTRACT In this study, we developed and validated a novel fiber bundle cell (FBC) framework to enable rapid, reliability‐anchored design of pseudo‐ductile thin‐ply carbon/glass hybrid composites.
László M. Vas, Roland Petrény
wiley   +1 more source

Progress Toward Efficient Wide‐Gap Cu(In,Ga)(S,Se)2 Thin‐Film Solar Cells

Progress in Photovoltaics: Research and Applications, EarlyView.
Wide‐gap Cu (In,Ga)(S,Se)2 thin‐film solar cells are studied in view of their performance, limitations, and opportunities for further optimization. Different sources of open circuit voltage limitations were discussed and weighted. Interface recombination appears the main recombination channel, which however can be influenced heavy alkali treatment ...
Setareh Zahedi‐Azad, Roland Scheer, Dimitrios Hariskos, Stefan Paetel, Wolfram Hempel, Wolfram Witte, Hao Luo, Oana Cojocaru‐Mirédin, Mary Blankenship, Dirk Hauschild, Victor van Maris, Lothar Weinhardt, Clemens Heske, Thomas Unold, José A. Márquez, Jasmin Seeger, Florian Wilhelmi, Michael Hetterich, Thomas Niesen, Patrick Eraerds, Thomas Dalibor, Xiaowei Jin, Reinhard Schneider, Dagmar Gerthsen, Di Wang, Christian Kübel   +25 more
wiley   +1 more source

Evolutionary-Conserved Allosteric Properties of Three Neuronal Calcium Sensor Proteins

Frontiers in Molecular Neuroscience, 2019
Neuronal Calcium Sensors (NCS) are highly conserved proteins specifically expressed in neurons. Calcium (Ca2+)-binding to their EF-hand motifs results in a conformational change, which is crucial for the recognition of a specific target and the ...
Valerio Marino, Valerio Marino, Daniele Dell'Orco   +2 more
doaj   +1 more source

FinTech and Environmental Sustainability: Evidence From Brazil

Sustainable Development, EarlyView.
ABSTRACT This study explores the dynamic interplay between economic growth and environmental sustainability from a FinTech perspective, using Brazil as a case study. While FinTech's contribution to green transformation, sustainable finance, and resource efficiency has gained increasing attention, a notable lack of empirical research remains to assess ...
Kemal Eyuboglu, Umut Uzar
wiley   +1 more source

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

Gallium Nitride‐Based Electrode Materials for Supercapacitors: From Wide Band Semiconductor to Energy Storage Platform

Small, EarlyView.
This review focuses on capability of Gallium Nitride (GaN)‐based supercapacitors, bordering the advancement from porous architecture to novel hybrid nanostructures. It systematically investigates synthesis approaches and charge storage mechanisms that generate remarkable energy densities and competent cyclic stability.
Farasat Haider, Batool Esmat, Ali Raza Kashif, Muhammad Shahid Khan, Akif Safeen, Basit Ali Khan, Karim Khan, Basit Ali   +7 more
wiley   +1 more source

Corporate Social Responsibility and Firm Performance: Investigating the Role of Management Innovation Through Marketing Intensity

Thunderbird International Business Review, EarlyView.
ABSTRACT This study investigates the relationship between Corporate Social Responsibility (CSR) and firm performance using panel data from 716 Chinese firms listed on the Shanghai and Shenzhen Stock from 2013 to 2019. It further examines the role of management innovation, specifically marketing intensity, in moderating the CSR–financial performance ...
Freeman Brobbey Owusu, Dafydd Mali, Adil El Fakir, Hafez Abdo, Albert Acheampong   +4 more
wiley   +1 more source

Peptide Charge Modulates Ion Binding to EF-Hand Motifs: A Molecular Dynamics Study

Rare earth elements (REEs), particularly lanthanides (Ln), are of significant interest due to their critical roles in modern technology and medicine. However, their extraction, isolation, and purification remain challenging. Lanmodulin (LanM), a recently discovered EF-hand protein, exhibits high affinity and selectivity for binding Ln3+ ions.
Bailey Hanson, Diana Lambropoulos, Madelyn Smith, Jian Hu, Pengfei Li   +4 more
openaire   +1 more source

Fronting in Old Catalan: Asymmetries between Narration and Reported Speech1

Transactions of the Philological Society, Volume 123, Issue 1, Page 1-28, March 2025.
Abstract This article explores the distribution, syntax, and information structure of XVS clauses in the narrative text and the reported speech of a thirteenth‐century Old Catalan chronicle, the Llibre dels Fets. It is shown that XVS occurs mainly within reported speech and in embedded clauses.
Afra Pujol i Campeny
wiley   +1 more source