Results 31 to 40 of about 28,276 (232)

The Dictyostelium discoideum FimA protein, unlike yeast and plant fimbrins, is regulated by calcium similar to mammalian plastins

Scientific Reports, 2023
Plastins, also known as fimbrins, are highly conserved eukaryotic multidomain proteins that are involved in actin-bundling. They all contain four independently folded Calponin Homology-domains and an N-terminal headpiece that is comprised of two calcium ...
Hiroaki Ishida, Andrew G. Woodman, Naoya Kitada, Tomoyasu Aizawa, Hans J. Vogel   +4 more
doaj   +1 more source

Structural Analysis of Uranyl Complexation by the EF‐Hand Motif of Calmodulin: Effect of Phosphorylation [PDF]

Chemistry – A European Journal, 2017
AbstractBetter understanding of uranyl–protein interactions is a prerequisite to predict uranium chemical toxicity in cells. The EF‐hand motif of the calmodulin site I is about thousand times more affine for uranyl than for calcium, and threonine phosphorylation increases the uranyl affinity by two orders of magnitude at pH 7.
Sauge-Merle, Sandrine, Brulfert, Florian, Pardoux, Romain, Solari, Pier Lorenzo, Lemaire, David, Safi, Samir, Guilbaud, Philippe, Simoni, Eric, Merroun, Mohamed Larbi, Berthomieu, C.   +9 more
openaire   +4 more sources

Amyloid Assembly Endows Gad m 1 with Biomineralization Properties

Biomolecules, 2018
Acid proteins capable of nucleating Ca2+ and displaying aggregation capacity play key roles in the formation of calcium carbonate biominerals. The helix-loop helix EF-hands are the most common Ca2+-binding motifs in proteins. Calcium is bound by the loop
Milagros Castellanos, Almudena Torres-Pardo, Rosa Rodríguez-Pérez, María Gasset   +3 more
doaj   +1 more source

Prediction and analysis of canonical EF hand loop and qualitative estimation of Ca²⁺ binding affinity.

PLoS ONE, 2014
The diversity of functions carried out by EF hand-containing calcium-binding proteins is due to various interactions made by these proteins as well as the range of affinity levels for Ca²⁺ displayed by them.
Mohit Mazumder, Narendra Padhan, Alok Bhattacharya, Samudrala Gourinath   +3 more
doaj   +1 more source

Characterization of a helix‐loop‐helix (EF hand) motif of silver hake parvalbumin isoform B [PDF]

Protein Science, 1997
AbstractParvalbumins are a class of calcium‐binding proteins characterized by the presence of several helix‐loop‐helix (EF‐hand) motifs. It is suspected that these proteins evolved via intragene duplication from a single EF‐hand. Silver hake parvalbumin (SHPV) consists of three EF‐type helix‐loop‐helix regions, two of which have the ability to bind ...
S P, Revett, G, King, J, Shabanowitz, D F, Hunt, K L, Hartman, T M, Laue, D J, Nelson   +6 more
openaire   +2 more sources

Plant Seed Peroxygenase Is an Original Heme-oxygenase with an EF-hand Calcium Binding Motif [PDF]

Journal of Biological Chemistry, 2006
A growing body of evidence indicates that phytooxylipins play important roles in plant defense responses. However, many enzymes involved in the biosynthesis of these metabolites are still elusive. We have purified one of these enzymes, the peroxygenase (PXG), from oat microsomes and lipid droplets. It is an integral membrane protein requiring detergent
Hanano, A., Burcklen, M., Flenet, M., Ivancich, A., Louwagie, M., Garin, J., Blee, E.   +6 more
openaire   +3 more sources

Identification and Functional Analysis of Two Ca2+-binding EF-hand Motifs in the B"/PR72 Subunit of Protein Phosphatase 2A*

Journal of Biological Chemistry, 2003
Protein phosphatase 2A (PP2A) is a multifunctional serine/threonine phosphatase that is critical to many cellular processes including cell cycle regulation and signal transduction.
V. Janssens, J. Jordens, I. Stevens, C. van Hoof, E. Martens, H. de Smedt, Y. Engelborghs, E. Waelkens, J. Goris   +8 more
semanticscholar   +1 more source

Determining the atomic charge of calcium ion requires the information of its coordination geometry in an EF-hand motif [PDF]

The Journal of Chemical Physics, 2021
It is challenging to parameterize the force field for calcium ions (Ca2+) in calcium-binding proteins because of their unique coordination chemistry that involves the surrounding atoms required for stability. In this work, we observed a wide variation in Ca2+ binding loop conformations of the Ca2+-binding protein calmodulin, which adopts the most ...
Pengzhi Zhang, Jaebeom Han, Piotr Cieplak, Margaret. S. Cheung   +3 more
openaire   +3 more sources

Swiprosin-1 is a novel actin bundling protein that regulates cell spreading and migration.

PLoS ONE, 2013
Protein functions are often revealed by their localization to specialized cellular sites. Recent reports demonstrated that swiprosin-1 is found together with actin and actin-binding proteins in the cytoskeleton fraction of human mast cells and NK-like ...
Min-Sung Kwon, Kyoung Ryoung Park, Young-Dae Kim, Bo-Ra Na, Hye-Ran Kim, Hak-Jong Choi, Indre Piragyte, Hyesung Jeon, Kyung Hwun Chung, Woo Keun Song, Soo Hyun Eom, Chang-Duk Jun   +11 more
doaj   +1 more source

Identification and Characterization of anEntamoeba histolytica Upstream Regulatory Element 3 Sequence-specific DNA-binding Protein Containing EF-hand Motifs*

Journal of Biological Chemistry, 2001
The hgl5 gene of Entamoeba histolytica is negatively regulated through the upstream regulatory element 3 (URE3) DNA motif TATTCTATT. This motif is also present and significant in the function of the E. histolytica fdx gene promoter.
C. Gilchrist, C. Holm, Molly A Hughes, J. Schaenman, B. Mann, W. Petri   +5 more
semanticscholar   +1 more source