Results 41 to 50 of about 28,276 (232)

Mechanism of Zn²⁺ and Ca²⁺ Binding to Human S100A1

Biomolecules, 2021
S100A1 is a member of the S100 family of small ubiquitous Ca2+-binding proteins, which participates in the regulation of cell differentiation, motility, and survival. It exists as homo- or heterodimers.
Viktoriia E. Baksheeva, Andrei Yu. Roman, Claude Villard, François Devred, Deborah Byrne, Dahbia Yatoui, Arthur O. Zalevsky, Alisa A. Vologzhannikova, Andrey S. Sokolov, Sergei E. Permyakov, Andrey V. Golovin, Gary S. Shaw, Philipp O. Tsvetkov, Evgeni Yu. Zernii   +13 more
doaj   +1 more source

Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence.

Journal of Biological Chemistry, 1993
A novel Ca(2+)-binding protein, tentatively designated reticulocalbin, has been identified and characterized. Reticulocalbin is a luminal protein of the endoplasmic reticulum with an M(r) of 44,000 as revealed by biochemical analysis and ...
Masayuki Ozawat, T. Muramatsu
semanticscholar   +1 more source

Mutations in the EF-Hand Motif Impair the Inactivation of Barium Currents of the Cardiac α1C Channel [PDF]

Biophysical Journal, 1998
Calcium-dependent inactivation has been described as a negative feedback mechanism for regulating voltage-dependent calcium influx in cardiac cells. Most recent evidence points to the C-terminus of the alpha1C subunit, with its EF-hand binding motif, as being critical in this process.
Bernatchez, G., Talwar, D., Parent, L.
openaire   +2 more sources

A novel predicted calcium-regulated kinase family implicated in neurological disorders. [PDF]

PLoS ONE, 2013
The catalogues of protein kinases, the essential effectors of cellular signaling, have been charted in Metazoan genomes for a decade now. Yet, surprisingly, using bioinformatics tools, we predicted protein kinase structure for proteins coded by five ...
Małgorzata Dudkiewicz, Anna Lenart, Krzysztof Pawłowski   +2 more
doaj   +1 more source

Blocking the interaction between S100A9 protein and RAGE V domain using S100A12 protein. [PDF]

PLoS ONE, 2018
The proteins S100A9 and S100A12 are associated with the human S100 calcium-binding protein family. These proteins promote interaction with target proteins and alter their conformation when they bind to calcium ions in EF-hand motifs. The V domain of RAGE
Revansiddha Katte, Chin Yu
doaj   +1 more source

Critical Determinants of Ca2+-Dependent Inactivation within an EF-Hand Motif of L-Type Ca2+ Channels [PDF]

Biophysical Journal, 2000
L-type (alpha(1C)) calcium channels inactivate rapidly in response to localized elevation of intracellular Ca(2+), providing negative Ca(2+) feedback in a diverse array of biological contexts. The dominant Ca(2+) sensor for such Ca(2+)-dependent inactivation has recently been identified as calmodulin, which appears to be constitutively tethered to the ...
Peterson, Blaise Z., Lee, Joanna S., Mulle, Jennifer G., Wang, Yan, de Leon, Marita, Yue, David T.   +5 more
openaire   +2 more sources

Modulation of CaV1.2 Channels by Mg2+ Acting at an EF-hand Motif in the COOH-terminal Domain [PDF]

The Journal of General Physiology, 2005
Magnesium levels in cardiac myocytes change in cardiovascular diseases. Intracellular free magnesium (Mgi) inhibits L-type Ca2+ currents through CaV1.2 channels in cardiac myocytes, but the mechanism of this effect is unknown. We hypothesized that Mgi acts through the COOH-terminal EF-hand of CaV1.2.
Brunet, Sylvain, Scheuer, Todd, Klevit, Rachel, Catterall, William A.   +3 more
openaire   +2 more sources

NADPH Oxidase Gene, FgNoxD, Plays a Critical Role in Development and Virulence in Fusarium graminearum

Frontiers in Microbiology, 2022
NADPH oxidase is an enzyme that generates reactive oxygen species from oxygen and NADPH and is highly conserved in eukaryotes. In Fusarium graminearum, a series of different Nox enzymes have been identified.
Taiying Li, Dohyun Kim, Jungkwan Lee
doaj   +1 more source

Calcium in the Backstage of Malaria Parasite Biology

Frontiers in Cellular and Infection Microbiology, 2021
The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle.
Lucas Silva de Oliveira, Lucas Silva de Oliveira, Marcos Rodrigo Alborghetti, Marcos Rodrigo Alborghetti, Renata Garcia Carneiro, Izabela Marques Dourado Bastos, Rogerio Amino, Philippe Grellier, Sébastien Charneau   +8 more
doaj   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

Advanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska, Yutong Luo, Ruyan Zhao, Jianjun Zhang, Mingchao Wang, Xinliang Feng, Eike Brunner, Stefan Kaskel   +7 more
wiley   +1 more source