Results 111 to 120 of about 15,149,930 (293)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Effect of the Suction on the Stability of a Silty Sand Slope [PDF]

open access: yes, 2019
This paper presents a revision of some of the models that have been proposed to estimate the strength of unsaturated soils. The theoretical results obtained from these models are compared with the experimental results of controlled suction triaxial tests
Mora-Ortiz, R.S., Slope, Effect
core  

The Method and Experiment of Micro-Crack Identification Using OFDR Strain Measurement Technology

open access: yesPhotonics
The precise evaluation of micro-crack sizes and locations is crucial for the safe operation of structures. Traditional detection techniques, however, suffer from low spatial resolution, making it difficult to accurately locate micrometer-scale cracks.
Bin Chen   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Further Thoughts on Double Effect: Some Preliminary Responses

open access: yes, 1991
Since the papers in this issue by Alan Donagan, Don Marquis, William Nelson and Warren Quinn raise complex and challenging questions about almost every aspect of my "Who is Entitled to Double Effect", I cannot, in the present context, provide more than ...
Boyle, Joseph
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Dependence Effect by Advertising Activities of Firm and Decline of Equilibrium Rate of Economic Growth

open access: yes, 2013
Advertising activities of firm in the affluent society of modern capitalist economy induce the consumer’s desire in demand of goods and services that has not existed ever in our society.
カイ, アキラ, 甲斐, 明, 336
core   +1 more source

Leveraging Attention Mechanisms in Neural Networks for High-Order Accuracy in Particle-in-Cell Simulations

open access: yesAdvances in Mathematical Physics
This paper introduces a novel approach to enhance the accuracy of charge density calculations in particle-in-cell (PIC) simulations by leveraging attention mechanisms in neural networks (NNs).
Jian-Nan Chen, Jun-Jie Zhang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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