Results 131 to 140 of about 15,149,930 (293)
Geochemical evaluation and driving factor analysis of soil salinization in Northeast China Plain
IntroductionThe Songnen Plain in Northeast China is considered as one of the world's three major saline-alkali land regions. However, the evaluation of the extent and degree of saline-alkali land has primarily been mainly obtained via remote sensing ...
Huimin Dai +20 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
We have evaluated a systematic effect on counts-in-cells analysis of deep, wide-field galaxy catalogues induced by the evolution of clustering within the survey volume.
Takahiko Matsubara, Light-Cone Effect
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Symposium no. 38 Paper no. 560 Presentation: poster 560-1
This study dealt with the reduction of soil loss from variously managed grass filter strips. Slope plots under a rainfall simulator were employed in this study.
Effect Of Grass
core
NIR-II light-driven transformable nanomedicine for precise deep-tissue photothermal therapy
Photothermal therapy (PTT) holds potential as a noninvasive cancer treatment but is challenged by limited tissue penetration due to physiological barriers. Here, we report that conditional extracellular matrix proteolysis augments deep-tissue PTT using a
Yizhuo Zhou +9 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
In vitro and in vivo observations accumulated over several decades have firmly shown that the biological effects of ionizing radiation can spread from irradiated cells/tissues to non-targeted cells/tissues. Redox-modulated intercellular communication mechanisms that include a role for secreted factors and gap junctions, can mediate these non-targeted ...
Lyng, Fiona M., Azzam, Edouard I.
openaire +3 more sources

