Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The relationship between transition shock and professional identity of nursing interns in China: a moderated mediation effect analysis. [PDF]
Front PsycholLiang S +6 more
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
CGRP-Targeting Therapies in Vestibular Migraine: A Synthesis of Observational Evidence with Direction-of-Effect Analysis. [PDF]
Med Sci (Basel)Ciubotaru A +13 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Stratification-based instrumental variable analysis framework for nonlinear effect analysis. [PDF]
BiostatisticsTian H, Patel A, Burgess S.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Clinical OphthalmologyYuehong Tan, Danyan Qin, Yi Zhou, Yan Ru, Xinxin Song Department of Nursing, Shanghai Eye Hospital Shanghai Eye Diseases Prevention and Treatment Center, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Danyan Qin,
Tan Y, Qin D, Zhou Y, Ru Y, Song X
doaj
RETRACTION: "Effect Analysis of Degranulated Cell in Early Fertilization on FET Outcome and Offspring Safety with Data Mining". [PDF]
Comput Math Methods MedAnd Mathematical Methods In Medicine C.
europepmc +1 more source
Wind speed and electricity demand correlation analysis in the Australian National Electricity Market
, 2015 This paper analyses wind speed and electricity demand correlation to determine the ability of wind turbine generators to meet electricity demand in the Australian National Electricity Market (NEM) without the aid of energy storage.
Phillip Wild +3 more
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