Results 201 to 210 of about 4,170,261 (261)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity. [PDF]

Life (Basel)
Namba T, Nishikimi M, Emoto R, Kikutani K, Ohshimo S, Matsui S, Shime N.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Long-term exposure to particulate air pollution associated with the progression of type 2 diabetes mellitus in China: effect size and urban-rural disparities. [PDF]

BMC Public Health
Hu M, Hao X, Zhang Y, Sun X, Zhang M, Zhao J, Wang Q.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pediatric cirrhotic cardiomyopathy: literature review and effect size estimations of selected parameters. [PDF]

Eur J Pediatr
Niculae AȘ, Căinap SS, Grama A, Pop TL.   +3 more
europepmc   +1 more source

Challenging the N-Heuristic: Effect size, not sample size, predicts the replicability of psychological science. [PDF]

PLoS One
Li X, Liu J, Gao W, Cohen GL.
europepmc   +1 more source

Multivariate testing and effect size measures for batch effect evaluation in radiomic features. [PDF]

Sci Rep
Horng H, Scott C, Winham S, Jensen M, Pantalone L, Mankowski W, Kerlikowske K, Vachon CM, Kontos D, Shinohara RT.   +9 more
europepmc   +1 more source

Advancing the reporting of pediatric EEG data: Tools for estimating reliability, effect size, and data quality metrics. [PDF]

Dev Cogn Neurosci
Xu W, Monachino AD, McCormick SA, Margolis ET, Sobrino A, Bosco C, Franke CJ, Davel L, Zieff MR, Donald KA, Gabard-Durnam LJ, Morales S.   +11 more
europepmc   +1 more source