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Heterogeneity of heterogeneities in neuronal networks [PDF]
Frontiers in Computational Neuroscience, 2014 Neurons in the brain exhibit a broad spectrum of heterogeneities even within a given morphological or physiological class. In a recent modeling study, Mejias and Longtin investigated the effects of heterogeneity in the voltage threshold for spike generation on the dynamics of random networks of excitatory and inhibitory neurons (Mejias and Longtin ...
Fabiano eBaroni +3 more
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Cancers, 2022 There is growing evidence that tumour heterogeneity has an imperative role in cancer development, evolution and resistance to therapy. Continuing advancements in biomedical research enable tumour heterogeneity to be observed and studied more critically.
Mei Fong Ng +2 more
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How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer
Biomedicines, 2021 Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of the main concerns regarding tumor progression and resistance to anti-
Elena Vinuesa-Pitarch +2 more
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Mitochondrial Heterogeneity [PDF]
Frontiers in Genetics, 2019 Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly mitochondria, is increasingly being recognised as an important explanatory factor in cell-to-cell heterogeneity.
Juvid Aryaman +6 more
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Cells, 2021 Tremendous data have been accumulated in the effort to understand chemoresistance of triple negative breast cancer (TNBC). However, modifications in cancer cells surviving combined and sequential treatment still remain poorly described. In order to mimic
Marie Winter +9 more
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Heterogeneous message passing for heterogeneous networks
Physical Review E, 2023 12 pages, 8 figures, 3 ...
George T. Cantwell +2 more
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EMBO Molecular Medicine, 2022 Breast cancer is the most frequent cancer among women, and metastases in distant organs are the leading cause of the cancer‐related deaths. While survival of early‐stage breast cancer patients has increased dramatically, the 5‐year survival rate of ...
Zora Baumann +2 more
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On the heterogeneity of terror [PDF]
European Economic Review, 2012 Most of the existing literature on the determinants of terrorism treats terror as a uniform phenomenon and does not distinguish between different types of terror. We argue that terror of different ideological types should have different determinants as the terror groups cater to different grievances, engage in compromise to different degrees and have ...
Kis-Katos, Krisztina +2 more
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Journal of Experimental & Clinical Cancer Research, 2022 Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez +20 more
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Cells, 2021 Polycomb repressive complex 2 (PRC2) mediates histone H3K27me3 methylation and the stable transcriptional repression of a number of gene expression programs involved in the control of cellular identity during development and differentiation.
Ludivine Raby +8 more
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