Results 21 to 30 of about 2,178,756 (313)
TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?
Membranes, 2023 Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ...
Mayar Soussi +2 more
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Heterogeneity in tuberculosis [PDF]
Nature Reviews Immunology, 2017 Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results in a range of clinical presentations in humans. Most infections manifest as a clinically asymptomatic, contained state that is termed latent TB infection (LTBI); a smaller subset of infected individuals present with symptomatic, active TB.
Anthony M, Cadena +2 more
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Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature
Hematology Reports, 2018 Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas(DLBCL) with extranodal localization represent clinically and molecularly distinct entities.
Stergios Boussios +8 more
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Chemotherapy Associated Ovarian Failure
Frontiers in Endocrinology, 2020 As the incidence of malignancies in young adults is increasing, fertility preservation in cancer survivors arises as a major concern. Especially among female cancer patients, pregnancy rates are estimated to be 40% lower compared to women of the same age.
Davide Mauri +10 more
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019 Introduction Symptomatic anti‐Alzheimer's disease (AD) drugs have been commonly used for the treatment of AD. Knowing the natural courses of patients with AD on placebo is highly relevant for clinicians to understand their efficacy and for investigators ...
Mitsunori Watanabe +15 more
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Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)
Bio-Protocol, 2020 The binding interactions of PD-1 and PD-L1 have been studied by surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) over the past few years, but these investigations resulted in controversy regarding the values of the dissociation ...
Magnez Romain +4 more
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Heterogeneous Agents Situated in Heterogeneous Spaces
Applied Artificial Intelligence, 2002 This paper introduces the Multi-layered Multi-Agent Situated System model (MMASS), a model for Multi-Agent Systems (MAS) situated in an environment. The main feature of the MMASS model is to give an explicit definition of the spatial structure of the environment in which the system of situated agents are acting and interacting.
BANDINI, STEFANIA +2 more
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Frontiers in Oncology, 2023 Head and Neck Squamous Cell Carcinoma (HNSCC) remains a cancer with a poor prognosis, with a 5-year survival rate of less than 50%. Although epidermal growth factor receptor (EGFR) is almost always overexpressed, targeted anti-EGFR therapies have modest ...
Martin Morisse +13 more
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Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?
Frontiers in Endocrinology, 2023 IntroductionReprogramming of cellular metabolism is now a hallmark of tumorigenesis. In recent years, research on pancreatic neuroendocrine tumors (pNETs) has focused on genetic and epigenetic modifications and related signaling pathways, but few studies
Arnaud Jannin +8 more
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Biomedicine Hub, 2023 Introduction: The quest for small molecule inhibitors of the PD-1/PD-L1 checkpoint continues in parallel to the extensive development of monoclonal antibodies directed against this immune checkpoint. Drug screening strategies are being set up to identify
Xavier Thuru +3 more
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