Results 21 to 30 of about 1,890,045 (316)

TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?

open access: yesMembranes, 2023
Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ...
Mayar Soussi   +2 more
doaj   +1 more source

Link-heterogeneity vs. node-heterogeneity in clusters [PDF]

open access: yes2010 International Conference on High Performance Computing, 2010
Heterogeneity in resources pervades all modern computing platforms. How do the effects of heterogeneity depend on which resources differ among computers in a platform? Some answers are derived within a formal framework, by comparing heterogeneity in computing power (node-heterogeneity) with heterogeneity in communication speed (link-heterogeneity). The
Beaumont, Olivier, Rosenberg, Arnold
openaire   +2 more sources

Representation Heterogeneity

open access: yesCoRR, 2022
Semantic Heterogeneity is conventionally understood as the existence of variance in the representation of a target reality when modelled, by independent parties, in different databases, schemas and/ or data. We argue that the mere encoding of variance, while being necessary, is not sufficient enough to deal with the problem of representational ...
Giunchiglia, Fausto, Bagchi, Mayukh
openaire   +3 more sources

Heterogeneous Agents Situated in Heterogeneous Spaces

open access: yesApplied Artificial Intelligence, 2002
This paper introduces the Multi-layered Multi-Agent Situated System model (MMASS), a model for Multi-Agent Systems (MAS) situated in an environment. The main feature of the MMASS model is to give an explicit definition of the spatial structure of the environment in which the system of situated agents are acting and interacting.
BANDINI, STEFANIA   +2 more
openaire   +3 more sources

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

open access: yesHematology Reports, 2018
Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas(DLBCL) with extranodal localization represent clinically and molecularly distinct entities.
Stergios Boussios   +8 more
doaj   +1 more source

Chemotherapy Associated Ovarian Failure

open access: yesFrontiers in Endocrinology, 2020
As the incidence of malignancies in young adults is increasing, fertility preservation in cancer survivors arises as a major concern. Especially among female cancer patients, pregnancy rates are estimated to be 40% lower compared to women of the same age.
Davide Mauri   +10 more
doaj   +1 more source

Analyses of natural courses of Japanese patients with Alzheimer's disease using placebo data from placebo‐controlled, randomized clinical trials: Japanese Study on the Estimation of Clinical course of Alzheimer's disease

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Symptomatic anti‐Alzheimer's disease (AD) drugs have been commonly used for the treatment of AD. Knowing the natural courses of patients with AD on placebo is highly relevant for clinicians to understand their efficacy and for investigators ...
Mitsunori Watanabe   +15 more
doaj   +1 more source

Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)

open access: yesBio-Protocol, 2020
The binding interactions of PD-1 and PD-L1 have been studied by surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) over the past few years, but these investigations resulted in controversy regarding the values of the dissociation ...
Magnez Romain   +4 more
doaj   +1 more source

Heterogeneity in tuberculosis [PDF]

open access: yesNature Reviews Immunology, 2017
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results in a range of clinical presentations in humans. Most infections manifest as a clinically asymptomatic, contained state that is termed latent TB infection (LTBI); a smaller subset of infected individuals present with symptomatic, active TB.
Anthony M, Cadena   +2 more
openaire   +2 more sources

Influence of EGF and pro-NGF on EGFR/SORTILIN interaction and clinical impact in head and neck squamous cell carcinoma

open access: yesFrontiers in Oncology, 2023
Head and Neck Squamous Cell Carcinoma (HNSCC) remains a cancer with a poor prognosis, with a 5-year survival rate of less than 50%. Although epidermal growth factor receptor (EGFR) is almost always overexpressed, targeted anti-EGFR therapies have modest ...
Martin Morisse   +13 more
doaj   +1 more source

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