Results 61 to 70 of about 7,937,923 (254)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Effective dose enhancement using gold as a radiation sensitizer: a Monte Carlo study [PDF]
, 2011 Despite years of research, a significant gap remains between the cancer burden requiring treatment and the mechanisms currently available in clinical settings.
Ahmed, Nabeel G.
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Complexity of Constraint Satisfaction Problems over Finite Subsets of Natural Numbers [PDF]
, 2016 We study the computational complexity of constraint satisfaction problems that are based on integer expressions and algebraic circuits. On input of a finite set of variables and a finite set of constraints the question is whether the variables can be ...
Dose, Titus
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
, 2016 Objectives: Explore the primary characteristics of afferent noisy stimuli, which optimally activate locomotor patterns at low intensity. Materials and Methods: Intracellular and extracellular electrophysiological traces were derived from single ...
Dose, Francesco +3 more
core +1 more source
P-Optimal Proof Systems for Each NP-Set but no Complete Disjoint NP-Pairs Relative to an Oracle [PDF]
, 2019 Pudlák [P. Pudlák, 2017] lists several major conjectures from the field of proof complexity and asks for oracles that separate corresponding relativized conjectures.
Dose, Titus
core +1 more source
Learning from the Prevention and Early Intervention Initiative in Ireland [PDF]
, 2016 Centre for Effective Services (CES)
core +6 more sources
Optimal designs for estimating critical effective dose under model uncertainty in a dose response study [PDF]
Toxicologists have been increasingly using a class of models to describe a continuous response in the last few years. This class consists of nested nonlinear models and is used for estimating various parameters in the models or some meaningful function ...
Shpilev, Piter +3 more
core +2 more sources