Results 81 to 90 of about 1,480,299 (262)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Analysis of natural uranium in groundwater of Kanchipuram district of Tamil Nadu, India

Radiation Protection and Environment
Groundwater serves as the primary source of drinking water in rural and urban India as well as in many regions worldwide. In this study, the levels of uranium were determined in groundwater samples collected from the Kanchipuram district using the ...
Suja Subramanian, Satyanarayan Bramha, Kothai Parthasarathy, R. Ravisankar, S. Chandrasekaran   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Initial Evaluation of Exposure of Adult Residents in Dange-Shuni Local Government Area to Radioactive Cesium (Cs-137) through Ingestion

UMYU Scientifica Journal
Radioactive Cesium (137-Cs) is widely used in hospitals as a gamma source for calibrating medical radiotherapy devices used in cancer treatment.  It is also employed to calibrate radiation detection instruments.
Aminu Saidu, Sabiu B Muhammad, Sulaiman A Ogunsina, Usman Abubakar, Junaidu Aliyu, Muttaka Umar, Abdullahi M Ibrahim, Bashir Abdullahi, Musa A Wasagu, Ibrahim M Danmalam, Mukhtar Abdulkadir   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Relationship Between Effective Dose, Alternative Metrics, and SSDE: Experiences with Two CT Dose-Monitoring Systems

Diagnostics
Background: We assessed the frequency and causes of discrepancies in CT dose indices such as dose-length product (DLP), size-specific dose estimate (SSDE), and effective dose (ED), as calculated by CT dose-monitoring systems.
Lilla Szatmáriné Egeresi, László Urbán, Zsolt Dankó, Ervin Balázs, Ervin Berényi, Mária Marosi, János Kiss, Péter Bágyi, Zita Képes, Miklós Emri, László Balkay   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Patient-specific Effective Dose Estimation from Dose–Length Product in Lung Computed Tomography Using Monte Carlo Simulation

Journal of Medical Signals and Sensors
Background: Computed tomography (CT) imaging has a large portion in the dose of patients from radiological procedures; therefore, accurate calculation of radiation risk estimation in this modality is inevitable.
Gholamreza Fallahmohammadi, Zeinab Kordzini Nodeh, Mohammad Mahdavi   +2 more
doaj   +1 more source