Results 81 to 90 of about 7,937,923 (254)

Practical considerations for optimal designs in clinical dose finding studies [PDF]

Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger, Pinheiro, José, Bretz, Frank   +2 more
core  

Ozone as U-shaped dose responses molecules (Hormetins)

, 2010
Redox environment involves a broad network of pro-oxidant and antioxidant components. Health benefit or damage can be induced as a consequence of an adaptive cellular stress response.
G. Martínez-Sánchez, A. Giuliani, G. Pérez Davison, L. Re, G. Pérez-Davison, G. Martinez Sanchez   +5 more
core   +1 more source

Determination of ED50 and ED95 for Ciprofol in Morbidly Obese Patients During Induction of General Anesthesia: A Single-Center, Up-and-Down Study Based on Lean Body Weight

Drug Design, Development and Therapy
Chao-min Wu, Ji-min Wu, Jian-xin Jiang, Qiao min Xu, Xue-hao Han, Gong-chen Duan Department of Anesthesiology, Lishui People’s Hospital, The First Affiliated Hospital of Lishui University, Wenzhou Medical University Lishui Hospital, Lishui, People’s ...
Wu CM, Wu JM, Jiang JX, Xu QM, Han XH, Duan GC   +5 more
doaj  

Size-Specific Dose Estimate and Effective Dose for Pediatric Computed Tomography

Journal of Medical Physics
The purpose of this study is to present the multivariate analysis of the size-specific dose estimate (SSDE) and E in pediatric computed tomography (CT) imaging.
Rukhsar Khan, Mudasir Ashraf Shah, Shagufta Wahab, Rizwan Ahmad Khan   +3 more
doaj   +1 more source

Comparison of Radiation Doses of Computed Tomography Brain and Pulmonary Angiography with International Commission on Radiological Protection Guidelines: A Descriptive Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Computed Tomography Angiography (CTA) is useful for evaluating and diagnosing conditions related to blood vessels, such as aneurysms, stenosis (narrowing of vessels), vascular malformations, and blockages.
AF Fidha, George Arattu Alphy, Dabholkar Digambar Amita   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A note on nonparametric estimation of the effective dose in quantal bioassay [PDF]

For the common binary response model we propose a direct method for the nonparametric estimation of the effective dose level ED? (0Binary response model,effective dose level,nonparametric regression,isotonic regression,order restricted inference,local ...
Dette, Holger, Neumeyer, Natalie, Pilz, Kay F.   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source