Results 101 to 110 of about 9,328,092 (295)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysis of radiation risk to patients from intra-operative use of the mobile X-ray system (C-arm)

Journal of Research in Medical Sciences, 2015
Background: The aim of this study was to investigate clinical applications of mobile C-arms and consequent radiation risk, to increase medical attention on radiation protection, and to provide basic data for safe radiation use in the operating room ...
Yang-Sub Lee, Hae-Kag Lee, Jae-Hwan Cho, Ham-Gyum Kim   +3 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Relationship Between Effective Dose, Alternative Metrics, and SSDE: Experiences with Two CT Dose-Monitoring Systems

Diagnostics
Background: We assessed the frequency and causes of discrepancies in CT dose indices such as dose-length product (DLP), size-specific dose estimate (SSDE), and effective dose (ED), as calculated by CT dose-monitoring systems.
Lilla Szatmáriné Egeresi, László Urbán, Zsolt Dankó, Ervin Balázs, Ervin Berényi, Mária Marosi, János Kiss, Péter Bágyi, Zita Képes, Miklós Emri, László Balkay   +10 more
doaj   +1 more source

Effective Dose Calculation in Critical Patients: A Comparative Analysis between Monte Carlo simulations and coefficient calculations

reservedIntroduzione: La tomografia computerizzata (TC) è una tecnica di imaging diagnostico; tuttavia, comporta un'esposizione significativa a radiazioni ionizzanti, rendendo necessaria una stima accurata della dose per garantire la sicurezza del ...
KANSO, ISSAM
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Analysis of natural uranium in groundwater of Kanchipuram district of Tamil Nadu, India

Radiation Protection and Environment
Groundwater serves as the primary source of drinking water in rural and urban India as well as in many regions worldwide. In this study, the levels of uranium were determined in groundwater samples collected from the Kanchipuram district using the ...
Suja Subramanian, Satyanarayan Bramha, Kothai Parthasarathy, R. Ravisankar, S. Chandrasekaran   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Initial Evaluation of Exposure of Adult Residents in Dange-Shuni Local Government Area to Radioactive Cesium (Cs-137) through Ingestion

UMYU Scientifica Journal
Radioactive Cesium (137-Cs) is widely used in hospitals as a gamma source for calibrating medical radiotherapy devices used in cancer treatment.  It is also employed to calibrate radiation detection instruments.  However, radioactive cesium-137 is one of
Aminu Saidu, Sabiu B Muhammad, Sulaiman A Ogunsina, Usman Abubakar, Junaidu Aliyu, Muttaka Umar, Abdullahi M Ibrahim, Bashir Abdullahi, Musa A Wasagu, Ibrahim M Danmalam, Mukhtar Abdulkadir   +10 more
doaj   +1 more source