Results 101 to 110 of about 7,937,923 (254)

Initial Evaluation of Exposure of Adult Residents in Dange-Shuni Local Government Area to Radioactive Cesium (Cs-137) through Ingestion

UMYU Scientifica Journal
Radioactive Cesium (137-Cs) is widely used in hospitals as a gamma source for calibrating medical radiotherapy devices used in cancer treatment.  It is also employed to calibrate radiation detection instruments.
Aminu Saidu, Sabiu B Muhammad, Sulaiman A Ogunsina, Usman Abubakar, Junaidu Aliyu, Muttaka Umar, Abdullahi M Ibrahim, Bashir Abdullahi, Musa A Wasagu, Ibrahim M Danmalam, Mukhtar Abdulkadir   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Biological effective doses in the intracavitary high dose rate brachytherapy of cervical cancer

, 2011
Purpose: The aim of this study is to evaluate the decrease of biological equivalent dose and its correlation withlocal/loco-regional control of tumour in the treatment of cervical cancer when the strength of the Ir-192 high dose rate(HDR) brachytherapy ...
L. Jaichand Singh, Y. Indibor Singh, Th. Tomcha Singh, Y. Sobita Devi, B. Arunkumar Sharma   +4 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Annual report 2012 - Centre for Effective Services

, 2013
The overall aim of the mid-term review was to consider the extent to which the Local and Community Development Programme was achieving its core aim, which is: to tackle poverty and social exclusion through partnership and constructive engagement ...
Centre for Effective Services
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Patient-specific Effective Dose Estimation from Dose–Length Product in Lung Computed Tomography Using Monte Carlo Simulation

Journal of Medical Signals and Sensors
Background: Computed tomography (CT) imaging has a large portion in the dose of patients from radiological procedures; therefore, accurate calculation of radiation risk estimation in this modality is inevitable.
Gholamreza Fallahmohammadi, Zeinab Kordzini Nodeh, Mohammad Mahdavi   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Evaluation of Radiation Dose and Image Quality in the Transition from Conventional Pelvimetry to Low-Dose Helical CT Pelvimetry

Tomography
Purpose: The present study aimed to assess the radiation dose associated with low-dose (LD) CT pelvimetry compared with conventional radiography and to evaluate the adequacy of the resulting image quality.
K. Shahgeldi, M. Parenmark, L. Claesson, T. M. Svahn   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source