Results 91 to 100 of about 7,937,923 (254)

Optimal designs for dose finding studies [PDF]

Identifying the "right" dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated ...
Dette, Holger, Bretz, Frank
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effective Dose Calculation in Critical Patients: A Comparative Analysis between Monte Carlo simulations and coefficient calculations

reservedIntroduzione: La tomografia computerizzata (TC) è una tecnica di imaging diagnostico; tuttavia, comporta un'esposizione significativa a radiazioni ionizzanti, rendendo necessaria una stima accurata della dose per garantire la sicurezza del ...
KANSO, ISSAM
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis of radiation risk to patients from intra-operative use of the mobile X-ray system (C-arm)

Journal of Research in Medical Sciences, 2015
Background: The aim of this study was to investigate clinical applications of mobile C-arms and consequent radiation risk, to increase medical attention on radiation protection, and to provide basic data for safe radiation use in the operating room ...
Yang-Sub Lee, Hae-Kag Lee, Jae-Hwan Cho, Ham-Gyum Kim   +3 more
doaj  

Relationship Between Effective Dose, Alternative Metrics, and SSDE: Experiences with Two CT Dose-Monitoring Systems

Diagnostics
Background: We assessed the frequency and causes of discrepancies in CT dose indices such as dose-length product (DLP), size-specific dose estimate (SSDE), and effective dose (ED), as calculated by CT dose-monitoring systems.
Lilla Szatmáriné Egeresi, László Urbán, Zsolt Dankó, Ervin Balázs, Ervin Berényi, Mária Marosi, János Kiss, Péter Bágyi, Zita Képes, Miklós Emri, László Balkay   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Analysis of natural uranium in groundwater of Kanchipuram district of Tamil Nadu, India

Radiation Protection and Environment
Groundwater serves as the primary source of drinking water in rural and urban India as well as in many regions worldwide. In this study, the levels of uranium were determined in groundwater samples collected from the Kanchipuram district using the ...
Suja Subramanian, Satyanarayan Bramha, Kothai Parthasarathy, R. Ravisankar, S. Chandrasekaran   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source