Results 91 to 100 of about 9,328,092 (295)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Determination of ED50 and ED95 for Ciprofol in Morbidly Obese Patients During Induction of General Anesthesia: A Single-Center, Up-and-Down Study Based on Lean Body Weight

Drug Design, Development and Therapy
Chao-min Wu, Ji-min Wu, Jian-xin Jiang, Qiao min Xu, Xue-hao Han, Gong-chen Duan Department of Anesthesiology, Lishui People’s Hospital, The First Affiliated Hospital of Lishui University, Wenzhou Medical University Lishui Hospital, Lishui, People’s ...
Wu CM, Wu JM, Jiang JX, Xu QM, Han XH, Duan GC   +5 more
doaj  

Size-Specific Dose Estimate and Effective Dose for Pediatric Computed Tomography

Journal of Medical Physics
The purpose of this study is to present the multivariate analysis of the size-specific dose estimate (SSDE) and E in pediatric computed tomography (CT) imaging.
Rukhsar Khan, Mudasir Ashraf Shah, Shagufta Wahab, Rizwan Ahmad Khan   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A comparison of computational methods for estimation of effective and organ doses to the patients from CT examination

Радиационная гигиена, 2017
The current study was devoted to estimation of effective and organ doses to the patients from the most common computed tomography (CT) examinations: head, chest, abdomen, chest+abdomen+pelvis in advanced scanners.
L. A. Chipiga
doaj   +1 more source

Effective dose and effective risk from post-SPECT imaging of the lumbar spine [PDF]

, 2016
Purpose Planar bone scans play an important role in the staging and monitoring of malignancy and metastases. Metastases in the lumbar spine are associated with significant morbidity, therefore accurate diagnosis is essential.
Hogg, P, Szczepura, Katy, McEntee, MF, Hogg, Peter, Tootell, Andrew; id_orcid, Szczepura, K, Tootell, AK, McEntee, Mark   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]

, 2012
The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source