Results 61 to 70 of about 103,119 (259)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

On the species scale, modular invariance and the gravitational EFT expansion

Journal of High Energy Physics
The concept of the species scale as the quantum gravity cut-off has been recently emphasised in the context of the Swampland program. Along these lines, we continue the quest for a precise understanding of its role within effective field theories of ...
A. Castellano, A. Herráez, L. E. Ibáñez   +2 more
doaj   +1 more source

Nonperturbative decoupling and effective field theory [PDF]

Physical Review D, 1995
12 pages no figures.
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effective field theories for muonic hydrogen

EPJ Web of Conferences, 2017
Experimental measurements of muonic hydrogen bound states have recently started to take place and provide a powerful setting in which to study the properties of QCD.
Peset Clara
doaj   +1 more source

Emergent supersymmetry in local equilibrium systems

Journal of High Energy Physics, 2018
Many physical processes we observe in nature involve variations of macroscopic quantities over spatial and temporal scales much larger than microscopic molecular collision scales and can be considered as in local thermal equilibrium.
Ping Gao, Hong Liu
doaj   +1 more source

Swampland constraints on 5d N $$ \mathcal{N} $$ = 1 supergravity

Journal of High Energy Physics, 2020
We propose Swampland constraints on consistent 5-dimensional N $$ \mathcal{N} $$ = 1 supergravity theories. We focus on a special class of BPS magnetic monopole strings which arise in gravitational theories.
Sheldon Katz, Hee-Cheol Kim, Houri-Christina Tarazi, Cumrun Vafa   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Relations between anomalous dimensions in the Regge limit

Journal of High Energy Physics
We extend the recent formalism developed for computing rapidity anomalous dimension of form factors using unitarity to the problem of high-energy near forward scattering.
Ira Z. Rothstein, Michael Saavedra
doaj   +1 more source