Results 81 to 90 of about 115,577 (299)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Emergent supersymmetry in local equilibrium systems
Journal of High Energy Physics, 2018 Many physical processes we observe in nature involve variations of macroscopic quantities over spatial and temporal scales much larger than microscopic molecular collision scales and can be considered as in local thermal equilibrium.
Ping Gao, Hong Liu
doaj +1 more source
Swampland constraints on 5d N $$ \mathcal{N} $$ = 1 supergravity
Journal of High Energy Physics, 2020 We propose Swampland constraints on consistent 5-dimensional N $$ \mathcal{N} $$ = 1 supergravity theories. We focus on a special class of BPS magnetic monopole strings which arise in gravitational theories.
Sheldon Katz +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Effective field theories for muonic hydrogen
EPJ Web of Conferences, 2017 Experimental measurements of muonic hydrogen bound states have recently started to take place and provide a powerful setting in which to study the properties of QCD.
Peset Clara
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
T T ¯ $$ T\overline{T} $$ -deformation and long range spin chains
Journal of High Energy Physics, 2020 We point out that two classes of deformations of integrable models, developed completely independently, have deep connections and share the same algebraic origin. One class includes the T T ¯ $$ T\overline{T} $$ -deformation of 1+1 dimensional integrable
Balázs Pozsgay +2 more
doaj +1 more source
Effective field theories and cosmological scattering equations
Journal of High Energy Physics, 2022 We propose worldsheet formulae for wavefunction coefficients of the massive non-linear sigma model (NLSM), scalar Dirac-Born-Infeld (DBI), and special Galileon (sGal) theories in de Sitter momentum space in terms of the recently proposed cosmological ...
C. Armstrong +4 more
doaj +1 more source
Currents in supersymmetric field theories [PDF]
, 2016 A general formalism to construct and improve supercurrents and source or anomaly superfields in two-derivative N = 1 supersymmetric theories is presented. It includes arbitrary gauge and chiral superfields and a linear superfield coupled to gauge fields.
Derendinger, Jean-Pierre +1 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source