Results 91 to 100 of about 115,577 (299)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Relations between anomalous dimensions in the Regge limit

open access: yesJournal of High Energy Physics
We extend the recent formalism developed for computing rapidity anomalous dimension of form factors using unitarity to the problem of high-energy near forward scattering.
Ira Z. Rothstein, Michael Saavedra
doaj   +1 more source

Introduction to the Effective Field Theory Description of Gravity

open access: yes, 1995
This is the pre-published version which is collected from arXiv.This is a pedagogical introduction to the treatment of general relativity as a quantum effective field theory.
Donoghue, John
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

D-dimensional modular assembly of higher-derivative four-point contact amplitudes involving fermions

open access: yesJournal of High Energy Physics
We present a novel robust framework for systematically constructing D-dimensional four-point higher-derivative contact amplitudes. Our modular block (“LEGO”-like) approach builds amplitudes directly from manifestly gauge-invariant kinematic blocks, color-
John Joseph M. Carrasco   +3 more
doaj   +1 more source

Conformal bootstrap at large charge

open access: yesJournal of High Energy Physics, 2018
We consider unitary CFTs with continuous global symmetries in d > 2. We consider a state created by the lightest operator of large charge Q ≫ 1 and analyze the correlator of two light charged operators in this state.
Daniel Jafferis   +2 more
doaj   +1 more source

Effective field theories of topological crystalline insulators and topological crystals

open access: yes, 2022
We present a general approach to obtain effective field theories for topological crystalline insulators whose low-energy theories are described by massive Dirac fermions. We show that these phases are characterized by the responses to spatially dependent
Huang, Sheng-Jie   +2 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Baryon junction and string interactions. Part II

open access: yesJournal of High Energy Physics
We study junctions between confining strings, extending the analysis of [Phys. Rev. D 110 (2024) 056018]. These junctions arise in Yang-Mills theories, and we focus on their universal low-energy dynamics.
Xuzixiang Lou, Siwei Zhong
doaj   +1 more source

Strings, branes, and gravity duals of gauge theories [PDF]

open access: yes, 2002
We study the correspondence between certain supersymmetric gauge theories and their dual supergravity descriptions. Using low-energy brane probes of the super-gravity geometries we find moduli spaces of vacua, as expected from considering the dual gauge ...
Lovis, Kenneth John
core  

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