Results 101 to 110 of about 581,012 (280)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease

Frontiers in Immunology, 2019
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections and hospitalization in infants under 1 year of age and there is currently no market-approved vaccine available.
Elisabeth A. van Erp, Elisabeth A. van Erp, Elisabeth A. van Erp, Willem Luytjes, Gerben Ferwerda, Gerben Ferwerda, Puck B. van Kasteren   +6 more
doaj   +1 more source

IMF isotopic properties in semi-peripheral collisions at Fermi energies

, 2005
We study the neutron and proton dynamical behavior along the fragmentation path in semi-peripheral collisions: 58Fe+58Fe (charge asymmetric, N/Z = 1.23) and 58Ni+58Ni (charge symmetric, N/Z = 1.07), at 47 AMeV.
Baran, Baran, Baran, Baran, Bertsch, Bertsch, Bocage, Casini, Chomaz, Colin, Colonna, Colonna, Danielewicz, Davin, Di Toro, Farine, Furnstahl, Gingras, Greco, Lefort, Li, Lukasik, M. Colonna, M. Di Toro, Mangiarotti, Milazzo, Montoya, Moustabchir, Pagano, R. Lionti, Shetty, Shetty, Shetty, Sobotka, Sobotka, Souliotis, Toke, Tsang, V. Baran   +38 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Development of multiplex microsatellite markers set for black currant (Ribes nigrum L.) genetic identification

Биотехнология и селекция растений
Background. At present, there is no effective technology for the genetic identification of black currant (Ribes nigrum L.) cultivars. Current solutions involve the amplification of genetic markers (microsatellites) in multiple tubes, which is relatively ...
M. V. Modorov, O. A. Kiseleva, M A. Polezhaeva, E. M. Chebotok   +3 more
doaj   +1 more source

Isospin in Reaction Dynamics. The Case of Dissipative Collisions at Fermi Energies

, 2005
A key question in the physics of unstable nuclei is the knowledge of the $EOS$ for asymmetric nuclear matter ($ANM$) away from normal conditions. We recall that the symmetry energy at low densities has important effects on the neutron skin structure ...
M. Di Toro, Via S. Sofia
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Development of Quantitative Competitive PCR and Absolute Based Real-Time PCR Assays for Quantification of The Butyrate Producing Bacterium: Butyrivibrio fibrisolvens

پژوهشهای علوم دامی ایران, 2016
Introduction Butyrivibrio fibrisolvens strains are presently recognized as the major butyrate-producing bacteria found in the rumen and digestive track of many animals and also in the human gut.
Mojtaba Tahmoorespur, Amir Taheri-Ghafarokhi, MohammadHadi Sekhavati   +2 more
doaj