Results 81 to 90 of about 582,070 (278)

Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae).

PLoS ONE, 2019
The South American plains vizcacha, Lagostomus maximus inhabits primarily the Pampean and adjoining Espinal, Monte and Chaquenean regions of Argentina. In order to study the population genetic structure of L.
María Constanza Gariboldi, Pablo Ignacio Felipe Inserra, Sergio Lucero, Mauricio Failla, Sergio Iván Perez, Alfredo Daniel Vitullo   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Engineering a new tripartite split-ccGFP system from Corynactis californica for detecting protein–protein interactions

Scientific Reports
Protein-protein interactions (PPIs) are critical to a range of biological processes and, consequently, aberrant interactions are implicated in many disorders.
Thomas M. Groseclose, Erin Kober, Jennifer Zupancic, Claire K. McLelland, Lexy A. Lujan, Yuliya A. Kunde, Sarah C. Mozden, Nileena Velappan, Antonietta M. Lillo, Emilia Solomon, Jacob Yoder, Geoffrey S. Waldo, Hau B. Nguyen   +12 more
doaj   +1 more source

Beyond predefined ligand libraries: a genetic algorithm approach for de novo discovery of catalysts for the Suzuki coupling reactions [PDF]

PeerJ Physical Chemistry
This study introduces a novel approach for the de novo design of transition metal catalysts, leveraging the power of genetic algorithms and density functional theory calculations.
Julius Seumer, Jan H. Jensen
doaj   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Development and characterization of a high-performance single-particle aerosol mass spectrometer (HP-SPAMS) [PDF]

Atmospheric Measurement Techniques
This study describes a high-performance single-particle mass spectrometry (HP-SPAMS) design in detail. The comprehensive improvements in the injection system, optical sizing system, mass spectrometry, and data acquisition system have improved particle ...
X. Du, X. Du, Q. Xie, Q. Xie, Q. Huang, Q. Huang, X. Li, X. Li, J. Yang, Z. Hou, J. Wang, X. Li, X. Li, Z. Zhou, Z. Zhou, Z. Huang, Z. Huang, W. Gao, W. Gao, L. Li, L. Li   +20 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Microfluidic System Based on Flexible Structures for Point-of-Care Device Diagnostics with Electrochemical Detection

Biosensors
Infectious diseases poses a growing public health challenge. The COVID-19 pandemic has further emphasized the urgent need for rapid, accessible diagnostics.
Kasper Marchlewicz, Robert Ziółkowski, Kamil Żukowski, Jakub Krzemiński, Elżbieta Malinowska   +4 more
doaj   +1 more source

Nuclear moments of the low-lying isomeric 1+ state of 34Al: Investigation on the neutron 1p1h excitation across N = 20 in the island of inversion

Physics Letters B, 2018
The nuclear g factor and quadrupole moment (Qs) have been measured for the low-lying isomeric 1+ state of 34Al, using the β-detected nuclear magnetic resonance (β-NMR) and quadrupole resonance (β-NQR) methods.
Z.Y. Xu, H. Heylen, K. Asahi, F. Boulay, J.M. Daugas, R.P. de Groote, W. Gins, O. Kamalou, Á. Koszorús, M. Lykiardopoulou, T.J. Mertzimekis, G. Neyens, H. Nishibata, T. Otsuka, R. Orset, A. Poves, T. Sato, C. Stodel, J.C. Thomas, N. Tsunoda, Y. Utsuno, M. Vandebrouck, X.F. Yang   +22 more
doaj   +1 more source