Results 71 to 80 of about 3,043,757 (303)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2005 Gilthead seabream (Sparus aurata) is one of the most important species among intensively reared fish in the Mediterranean region. Although there is a considerable interest in the genetic improvement of this species, many of the genetic parameters of ...
McAndrew, Brendan +2 more
core +1 more source
Assessing the genetic diversity in small farm animal populations*
Animal, 2011 Genetic variation is vital for the populations to adapt to varying environments and to respond to artificial selection; therefore, any conservation and development scheme should start from assessing the state of variation in the population.
M.A. Toro +4 more
doaj +1 more source
Ecology and Evolution, 2021 The consequences of poor breed management and inbreeding can range from gradual declines in individual productivity to more serious fertility and mortality concerns.
Andrew Dell +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
F-LMM: Grounding Frozen Large Multimodal Models
Endowing Large Multimodal Models (LMMs) with visual grounding capability can significantly enhance AIs’ understanding of the visual world and their interaction with humans.
Liu, Wentao +6 more
core +1 more source
The Effect Size in Uncertainty Analysis
Value in Health, 2010 In model-based health economic evaluation, uncertainty analysis is often done using parametric bootstrapping. This requires specifying probability distributions for the model variables that are uncertain.The effect size of the intervention is often expressed as a relative risk, and the standard assumption for a relative risk is that it has a lognormal ...
openaire +5 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Estimating effective population size using RADseq: Effects of SNP selection and sample size
Ecology and Evolution, 2020 Effective population size (Ne) is a key parameter of population genetics. However, Ne remains challenging to estimate for natural populations as several factors are likely to bias estimates.
Florianne Marandel +5 more
doaj +1 more source